The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
05
02
2019
revised:
18
04
2019
accepted:
19
04
2019
pubmed:
24
5
2019
medline:
18
9
2020
entrez:
24
5
2019
Statut:
ppublish
Résumé
Nucleotide-binding domain, leucine-rich repeat (NLR) proteins constitute a diverse class of innate immune sensors that detect pathogens or stress-associated stimuli in plants and animals. Some NLRs are activated upon direct binding to pathogen-derived ligands. In contrast, we focus here on a vertebrate NLR called NLRP1 that responds to the enzymatic activities of pathogen effectors. We discuss a newly proposed 'functional degradation' mechanism that explains activation and assembly of NLRP1 into an oligomeric complex called an inflammasome. We also discuss how NLRP1 is activated by non-pathogen-associated triggers such as the anti-cancer drug Val-boroPro, or by human disease-associated mutations. Finally, we discuss how research on NLRP1 has led to additional biological insights, including the unexpected discovery of a new CARD8 inflammasome.
Identifiants
pubmed: 31121538
pii: S0952-7915(18)30132-8
doi: 10.1016/j.coi.2019.04.015
pmc: PMC6800612
mid: NIHMS1527833
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Apoptosis Regulatory Proteins
0
CARD Signaling Adaptor Proteins
0
CARD8 protein, human
0
Inflammasomes
0
NLR Proteins
0
NLRP1 protein, human
0
Neoplasm Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-45Subventions
Organisme : NIAID NIH HHS
ID : P01 AI063302
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI075039
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI075039
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Références
Cell Chem Biol. 2017 Apr 20;24(4):507-514.e4
pubmed: 28392147
Cell Chem Biol. 2018 Mar 15;25(3):262-267.e5
pubmed: 29396289
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14408-13
pubmed: 23940371
Mol Cell. 2009 Mar 27;33(6):692-703
pubmed: 19328064
Nat Immunol. 2008 Oct;9(10):1171-8
pubmed: 18724372
Nat Med. 2018 Aug;24(8):1151-1156
pubmed: 29967349
Science. 2017 Nov 17;358(6365):888-893
pubmed: 29146805
EMBO Rep. 2018 Jan;19(1):89-101
pubmed: 29191979
Cell Host Microbe. 2010 Nov 18;8(5):455-62
pubmed: 21075356
Infect Immun. 2014 Jan;82(1):460-8
pubmed: 24218483
Nature. 2011 Sep 14;477(7366):596-600
pubmed: 21918512
Cell. 2015 May 21;161(5):1074-1088
pubmed: 26000483
J Immunol. 2013 Oct 15;191(8):3986-9
pubmed: 24043898
Infect Immun. 2017 Oct 18;85(11):
pubmed: 28808162
Cell Microbiol. 2008 Feb;10(2):332-43
pubmed: 17850338
Nat Struct Mol Biol. 2008 Dec;15(12):1293-301
pubmed: 18997778
PLoS One. 2011;6(11):e27396
pubmed: 22087307
Protein Sci. 2011 Aug;20(8):1298-345
pubmed: 21633985
Infect Immun. 2013 Feb;81(2):570-9
pubmed: 23230290
Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):358-366
pubmed: 30622213
PLoS One. 2013;8(3):e58860
pubmed: 23554941
Immunol Rev. 2015 May;265(1):22-34
pubmed: 25879281
Cell Microbiol. 2008 Jun;10(6):1352-62
pubmed: 18266992
Cell. 2015 May 21;161(5):1089-1100
pubmed: 26000484
Genome Res. 2011 Oct;21(10):1686-94
pubmed: 21795384
MBio. 2014 Feb 18;5(1):null
pubmed: 24549849
Cell Host Microbe. 2007 Mar 15;1(1):77-83
pubmed: 18005683
Cell. 2016 Sep 22;167(1):187-202.e17
pubmed: 27662089
PLoS Pathog. 2016 Dec 7;12(12):e1006052
pubmed: 27926929
Science. 2016 Dec 2;354(6316):
pubmed: 27934708
J Histochem Cytochem. 2007 May;55(5):443-52
pubmed: 17164409
Cancer Res. 2004 Aug 1;64(15):5471-80
pubmed: 15289357
J Mol Biol. 2012 Apr 6;417(4):336-50
pubmed: 22310050
Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13
pubmed: 2700931
Cell Chem Biol. 2019 Jun 20;26(6):901-907.e6
pubmed: 31006619
Infect Immun. 2009 Oct;77(10):4455-62
pubmed: 19651869
J Mol Biol. 2014 Dec 12;426(24):3935-3945
pubmed: 25451782
Cell Host Microbe. 2009 Jul 23;6(1):10-21
pubmed: 19616762
PLoS Pathog. 2013;9(6):e1003452
pubmed: 23818853
Annu Rev Genet. 2012;46:677-700
pubmed: 23145935
J Biol Chem. 2018 Dec 7;293(49):18864-18878
pubmed: 30291141
Infect Immun. 2014 Sep;82(9):3697-703
pubmed: 24935976
Annu Rev Biochem. 2012;81:261-89
pubmed: 22524314
Nat Genet. 2006 Feb;38(2):240-4
pubmed: 16429160
Nat Chem Biol. 2017 Jan;13(1):46-53
pubmed: 27820798
J Biol Chem. 2012 Jul 20;287(30):25030-7
pubmed: 22665479
Infect Immun. 1999 Jun;67(6):3055-60
pubmed: 10338520
Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13242-13247
pubmed: 29180436
J Biol Chem. 2007 Nov 23;282(47):34260-7
pubmed: 17878154
Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4254-63
pubmed: 25246571
PLoS One. 2012;7(11):e49741
pubmed: 23152930
Ann Rheum Dis. 2017 Jul;76(7):1191-1198
pubmed: 27965258
Mol Cell. 2002 Aug;10(2):417-26
pubmed: 12191486
Science. 2019 Apr 5;364(6435):
pubmed: 30872533
Science. 2019 Apr 5;364(6435):82-85
pubmed: 30872531
PLoS Pathog. 2012;8(4):e1002659
pubmed: 22536155
Nature. 2006 Nov 16;444(7117):323-9
pubmed: 17108957
Science. 2004 May 7;304(5672):843-6
pubmed: 15073321
J Immunol. 2010 Jan 1;184(1):17-20
pubmed: 19949100
PLoS Pathog. 2014 Mar 13;10(3):e1003927
pubmed: 24626226
Curr Rheumatol Rep. 2018 May 30;20(7):40
pubmed: 29846819
Immunity. 2017 Apr 18;46(4):649-659
pubmed: 28410991
Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4312-7
pubmed: 18337499
Nat Rev Immunol. 2016 Jul;16(7):407-20
pubmed: 27291964
Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4822-7
pubmed: 22411828
PLoS Pathog. 2010 Dec 09;6(12):e1001222
pubmed: 21170303
PLoS Pathog. 2012;8(3):e1002638
pubmed: 22479187
Cell. 2016 May 5;165(4):792-800
pubmed: 27153493
Immunity. 2008 Mar;28(3):285-7
pubmed: 18341998
Mol Microbiol. 1994 Sep;13(6):1093-100
pubmed: 7854123