Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model.
DNA
IL-36
Zika
adjuvant
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
22 May 2019
22 May 2019
Historique:
received:
04
04
2019
revised:
17
05
2019
accepted:
18
05
2019
entrez:
25
5
2019
pubmed:
28
5
2019
medline:
28
5
2019
Statut:
epublish
Résumé
Identification of novel molecular adjuvants which can boost and enhance vaccine-mediated immunity and provide dose-sparing potential against complex infectious diseases and for immunotherapy in cancer is likely to play a critical role in the next generation of vaccines. Given the number of challenging targets for which no or only partial vaccine options exist, adjuvants that can address some of these concerns are in high demand. Here, we report that a designed truncated Interleukin-36 gamma (IL-36 gamma) encoded plasmid can act as a potent adjuvant for several DNA-encoded vaccine targets including human immunodeficiency virus (HIV), influenza, and Zika in immunization models. We further show that the truncated IL-36 gamma (opt-36γt) plasmid provides improved dose sparing as it boosts immunity to a suboptimal dose of a Zika DNA vaccine, resulting in potent protection against a lethal Zika challenge.
Identifiants
pubmed: 31121939
pii: vaccines7020042
doi: 10.3390/vaccines7020042
pmc: PMC6632123
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH Pharmacology training grant
ID : T32 GM008076
Organisme : HIV Pathogenesis grant
ID : T32 AI007632
Organisme : NIAID grant
ID : U19 AI 109646
Références
J Immunol. 1999 Mar 1;162(5):2912-21
pubmed: 10072541
J Biol Chem. 2000 Jan 14;275(2):1169-75
pubmed: 10625660
J Biol Chem. 2000 Apr 7;275(14):10308-14
pubmed: 10744718
Vaccine. 2001 Mar 21;19(17-19):2673-80
pubmed: 11257408
J Immunol. 2001 Aug 1;167(3):1440-6
pubmed: 11466363
J Virol. 2001 Nov;75(22):10991-1001
pubmed: 11602739
J Biol Chem. 2004 Apr 2;279(14):13677-88
pubmed: 14734551
J Med Primatol. 2005 Oct;34(5-6):262-70
pubmed: 16128921
DNA Cell Biol. 2006 Jul;25(7):383-92
pubmed: 16848679
Vaccine. 2007 Mar 30;25(14):2541-4
pubmed: 17240491
Vaccine. 2007 Jun 21;25(26):4967-82
pubmed: 17335943
Immunity. 2007 Nov;27(5):687-90
pubmed: 18031690
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10501-6
pubmed: 18650390
Vaccine. 2008 Dec 9;26(52):6777-83
pubmed: 18835576
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3877-82
pubmed: 19237568
Sci Transl Med. 2010 Jan 20;2(15):15ra5
pubmed: 20371470
Vaccine. 2011 Mar 16;29(13):2461-73
pubmed: 21256188
Expert Rev Vaccines. 2011 Apr;10(4):463-70
pubmed: 21506644
Vaccine. 2011 Sep 22;29(41):7173-81
pubmed: 21651948
Blood. 2011 Nov 24;118(22):5813-23
pubmed: 21860022
J Biol Chem. 2011 Dec 9;286(49):42594-602
pubmed: 21965679
N Engl J Med. 2011 Oct 13;365(15):1406-16
pubmed: 21995388
PLoS One. 2012;7(1):e29231
pubmed: 22242162
Parasitol Res. 2012 Jul;111(1):403-11
pubmed: 22350714
Expert Rev Vaccines. 2012 Mar;11(3):349-66
pubmed: 22380826
Curr Opin Pharmacol. 2012 Aug;12(4):486-90
pubmed: 22398321
Hum Vaccin Immunother. 2012 Nov 1;8(11):1620-9
pubmed: 22894956
Blood. 2012 Oct 25;120(17):3478-87
pubmed: 22968459
J Clin Invest. 2012 Nov;122(11):3965-76
pubmed: 23064362
J Dermatol. 2013 Sep;40(9):749-51
pubmed: 23834760
J Infect Dis. 2013 Sep 1;208(5):818-29
pubmed: 23840043
Joint Bone Spine. 2013 Oct;80(5):449-53
pubmed: 23849463
Semin Immunol. 2013 Apr;25(2):130-45
pubmed: 23850011
Semin Immunol. 2013 Dec 15;25(6):389-93
pubmed: 24275600
Nat Med. 2013 Dec;19(12):1597-608
pubmed: 24309663
Semin Immunol. 2013 Dec 15;25(6):458-65
pubmed: 24355486
J Immunol. 2014 Jun 15;192(12):6053-61
pubmed: 24829417
J Eur Acad Dermatol Venereol. 2016 Feb;30(2):302-5
pubmed: 25688670
Front Immunol. 2015 Apr 29;6:207
pubmed: 25972874
J Virol. 2015 Sep;89(18):9154-66
pubmed: 26085155
Hum Vaccin Immunother. 2015;11(8):1972-82
pubmed: 26091432
Cancer Cell. 2015 Sep 14;28(3):296-306
pubmed: 26321222
Clin Exp Immunol. 2016 May;184(2):159-73
pubmed: 26701127
Cell Rep. 2016 Feb 2;14(4):708-722
pubmed: 26776523
Emerg Microbes Infect. 2016 Mar 23;5:e25
pubmed: 27004761
FEBS Open Bio. 2016 Mar 12;6(4):338-48
pubmed: 27239446
Cytokine. 2016 Aug;84:88-98
pubmed: 27259168
Front Microbiol. 2016 Jun 17;7:955
pubmed: 27379082
Hum Vaccin Immunother. 2017 Jan 2;13(1):19-33
pubmed: 27636098
Methods Mol Biol. 2017;1494:1-13
pubmed: 27718182
Adv Exp Med Biol. 2016;941:21-29
pubmed: 27734407
J Allergy Clin Immunol. 2017 Jul;140(1):109-120
pubmed: 28043870
Mucosal Immunol. 2017 Sep;10(5):1320-1334
pubmed: 28176791
Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2748-E2757
pubmed: 28289191
Hum Vaccin Immunother. 2017 Aug 3;13(8):1789-1797
pubmed: 28426274
Sci Rep. 2017 Jul 19;7(1):5799
pubmed: 28724920
Arch Dermatol Res. 2017 Oct;309(8):673-678
pubmed: 28852851
Int J Med Sci. 2017 Aug 18;14(10):1002-1007
pubmed: 28924372
Sci Transl Med. 2017 Oct 11;9(411):null
pubmed: 29021166
PLoS Pathog. 2017 Nov 22;13(11):e1006737
pubmed: 29166668
NPJ Vaccines. 2016 Nov 10;1:16021
pubmed: 29263859
J Invest Dermatol. 2018 Jun;138(6):1338-1347
pubmed: 29288651
Oncotarget. 2017 Dec 1;9(2):2895-2901
pubmed: 29416822
J Immunol. 2018 Jul 1;201(1):167-182
pubmed: 29794016
J Immunol. 2018 Jul 15;201(2):627-634
pubmed: 29891557
Cytokine. 2018 Nov;111:63-71
pubmed: 30118914
Semin Immunol. 2018 Oct;39:30-34
pubmed: 30122362
Nurs Womens Health. 2018 Oct;22(5):417-422
pubmed: 30145235
J Interferon Cytokine Res. 2018 Oct;38(10):423-439
pubmed: 30328794
J Invest Dermatol. 2019 Apr;139(4):848-858
pubmed: 30395846
BMC Med Genet. 2019 Jan 11;20(1):10
pubmed: 30634937
PLoS Negl Trop Dis. 2019 Feb 7;13(2):e0007042
pubmed: 30730897
J Immunol. 1997 Jan 15;158(2):816-26
pubmed: 8992999
J Virol. 1998 Feb;72(2):1497-503
pubmed: 9445053