Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.

Amacrine Cells / physiology Animals Axons / physiology Cilia / metabolism Insulin-Like Growth Factor I / pharmacology Mice Mice, Inbred C57BL Nerve Crush Nerve Growth Factor / physiology Nerve Regeneration / physiology Optic Nerve Injuries / pathology RNA-Binding Proteins / genetics Receptor, IGF Type 1 / metabolism Receptors, Presynaptic / physiology Retina / metabolism Retinal Ganglion Cells / drug effects

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
03 07 2019
Historique:
received: 29 10 2018
revised: 01 03 2019
accepted: 23 04 2019
pubmed: 28 5 2019
medline: 23 10 2019
entrez: 25 5 2019
Statut: ppublish

Résumé

Despite robust effects on immature neurons, growth factors minimally promote axon regeneration in the adult central nervous system (CNS). Attempting to improve growth-factor responsiveness in mature neurons by dedifferentiation, we overexpressed Lin28 in the retina. Lin28-treated retinas responded to insulin-like growth factor-1 (IGF1) by initiating retinal ganglion cell (RGC) axon regeneration after axotomy. Surprisingly, this effect was cell non-autonomous. Lin28 expression was required only in amacrine cells, inhibitory neurons that innervate RGCs. Ultimately, we found that optic-nerve crush pathologically upregulated activity in amacrine cells, which reduced RGC electrical activity and suppressed growth-factor signaling. Silencing amacrine cells or pharmacologically blocking inhibitory neurotransmission also induced IGF1 competence. Remarkably, RGCs regenerating across these manipulations localized IGF1 receptor to their primary cilia, which maintained their signaling competence and regenerative ability. Thus, our results reveal a circuit-based mechanism that regulates CNS axon regeneration and implicate primary cilia as a regenerative signaling hub.

Identifiants

DOI: 10.1016/j.neuron.2019.04.033 PMID: 31122676 PMC: PMC7350660
pubmed: 31122676
pii: S0896-6273(19)30390-3
doi: 10.1016/j.neuron.2019.04.033
pmc: PMC7350660
mid: NIHMS1528324
pii:
doi:

Substances chimiques

Lin-28 protein, mouse 0
RNA-Binding Proteins 0
Receptors, Presynaptic 0
Insulin-Like Growth Factor I 67763-96-6
Nerve Growth Factor 9061-61-4
Receptor, IGF Type 1 EC 2.7.10.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

39-51.e5

Subventions

Organisme : NEI NIH HHS
ID : R01 EY029869
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY015573
Pays : United States
Organisme : NICHD NIH HHS
ID : P30 HD018655
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY012196
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027411
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026978
Pays : United States
Organisme : BLRD VA
ID : IK6 BX005230
Pays : United States
Organisme : BLRD VA
ID : I01 BX000764
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY023341
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Yiling Zhang (Y)

F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.

Philip R Williams (PR)

F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: prwillia@wustl.edu.

Anne Jacobi (A)

F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.

Chen Wang (C)

F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.

Anurag Goel (A)

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Arlene A Hirano (AA)

Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; United States Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Nicholas C Brecha (NC)

Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; United States Veterans Administration Greater Los Angeles Healthcare System, Los Angeles, CA, USA.

Daniel Kerschensteiner (D)

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Zhigang He (Z)

F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, Boston, MA, USA.

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Classifications MeSH

questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules amacrines › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Eucaryotes › Animaux › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Cellules › Structures cellulaires › Prolongements cytoplasmiques › Cils vibratiles › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Somatomédines › Facteur de croissance IGF-I › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de neurochirurgie › Dénervation › Écrasement de nerf › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Facteurs de croissance nerveuse › Facteur de croissance nerveuse › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Régénération nerveuse › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions traumatiques des nerfs crâniens › Lésions traumatiques du nerf optique › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs des somatomédines › Récepteur IGF de type 1 › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs présynaptiques › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Organes des sens › Oeil › Rétine › Elevating Growth Factor Responsiveness and...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules ganglionnaires rétiniennes › Elevating Growth Factor Responsiveness and...