FOETAL for NCD-FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life: a prospective preconception study in rural Tanzania.
Adult
Anemia
/ diagnosis
Child Development
Epidemiological Monitoring
Epigenomics
Female
Health Services Needs and Demand
Humans
Infant, Newborn
Malaria
/ epidemiology
Noncommunicable Diseases
/ epidemiology
Preconception Care
/ methods
Pregnancy
Pregnancy Complications, Hematologic
/ diagnosis
Prenatal Exposure Delayed Effects
/ diagnosis
Risk Assessment
Risk Factors
Tanzania
/ epidemiology
Women's Health
/ standards
anemia
developmental programming
embryology
epigenetics
malaria
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
22 05 2019
22 05 2019
Historique:
entrez:
25
5
2019
pubmed:
28
5
2019
medline:
10
5
2020
Statut:
epublish
Résumé
Low-income and middle-income countries such as Tanzania experience a high prevalence of non-communicable diseases (NCDs), including anaemia. Studying if and how anaemia affects growth, placenta development, epigenetic patterns and newborns' risk of NCDs may provide approaches to prevent NCDs. The FOETALforNCD (FOetal Exposure and Epidemiological Transitions: the role of Anaemia in early Life for Non-Communicable Diseases in later life) Study is a population-based preconception, pregnancy and birth cohort study (n=1415, n=538, n=427, respectively), conducted in a rural region of North-East Tanzania. All participants were recruited prior to conception or early in pregnancy and followed throughout pregnancy as well as at birth. Data collection included: maternal blood, screening for NCDs and malaria, ultrasound in each trimester, neonatal anthropometry at birth and at 1 month of age, cord blood, placental and cord biopsies for stereology and epigenetic analyses. At preconception, the average age, body mass index and blood pressure of the women were 28 years, 23 kg/m The project will provide new knowledge on how health, even before conception, might modify the risk of developing NCDs and how to promote better health during pregnancy. The present project ended data collection 1 month after giving birth, but follow-up is continuing through regular monitoring of growth and development and health events according to the National Road Map Strategic Plan in Tanzania. This data will link fetal adverse event to childhood development, and depending on further grant allocation, through a life course follow-up.
Identifiants
pubmed: 31122967
pii: bmjopen-2018-024861
doi: 10.1136/bmjopen-2018-024861
pmc: PMC6537995
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e024861Commentaires et corrections
Type : ErratumIn
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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