Constitutive alterations in vesicular trafficking increase the sensitivity of cells from celiac disease patients to gliadin.
Adolescent
Case-Control Studies
Celiac Disease
/ immunology
Child
Child, Preschool
Endocytosis
/ immunology
Endosomes
/ immunology
Enterocytes
/ immunology
ErbB Receptors
/ metabolism
Fibroblasts
/ immunology
Gliadin
/ immunology
Humans
Immunity, Innate
Interleukin-15
/ metabolism
Intestinal Mucosa
/ immunology
Peptide Fragments
/ immunology
Th1 Cells
/ immunology
Coeliac disease
Endosomes
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
05
2018
accepted:
19
04
2019
entrez:
25
5
2019
pubmed:
28
5
2019
medline:
28
5
2019
Statut:
epublish
Résumé
Celiac Disease (CD) is an autoimmune disease characterized by inflammation of the intestinal mucosa due to an immune response to wheat gliadins. Some gliadin peptides (e.g., A-gliadin P57-68) induce an adaptive Th1 pro-inflammatory response. Other gliadin peptides (e.g., A-gliadin P31-43) induce a stress/innate immune response involving interleukin 15 (IL15) and interferon α (IFN-α). In the present study, we describe a stressed/inflamed celiac cellular phenotype in enterocytes and fibroblasts probably due to an alteration in the early-recycling endosomal system. Celiac cells are more sensitive to the gliadin peptide P31-43 and IL15 than controls. This phenotype is reproduced in control cells by inducing a delay in early vesicular trafficking. This constitutive lesion might mediate the stress/innate immune response to gliadin, which can be one of the triggers of the gliadin-specific T-cell response.
Identifiants
pubmed: 31123714
doi: 10.1038/s42003-019-0443-1
pii: 443
pmc: PMC6527696
doi:
Substances chimiques
IL15 protein, human
0
Interleukin-15
0
Peptide Fragments
0
gliadin p31-43
0
Gliadin
9007-90-3
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
190Commentaires et corrections
Type : ErratumIn
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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