Cell-Based Assays Using Differentiated Human Induced Pluripotent Cells.

Cell Differentiation Cell Line Chromatography, Liquid Drug Discovery Fluorometry High-Throughput Screening Assays Humans Induced Pluripotent Stem Cells / chemistry Metabolomics Microfluidics Optical Imaging Proteomics Tandem Mass Spectrometry
Differentiation protocols Disease models Induced pluripotent cell iPSC

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2019
Historique:
entrez: 25 5 2019
pubmed: 28 5 2019
medline: 13 3 2020
Statut: ppublish

Résumé

This chapter describes the requirements and preconditions for using human induced pluripotent cell lines in assay development within the pharmaceutical industry. The joint collaborative effort between academic and pharma partners within the StemBANCC consortium which enabled the implementation of iPSC-derived cellular models for drug discovery is highlighted. This large collaborative scientific network has successfully derived a significant number of well-characterized patient-specific iPSC lines and established disease-relevant cellular assays, both of which are requirements for enabling pharmaceutical companies to develop more efficacious and safer medicines.

Identifiants

DOI: 10.1007/978-1-4939-9477-9_1 PMID: 31124100
pubmed: 31124100
doi: 10.1007/978-1-4939-9477-9_1
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-14

Auteurs

Zameel Cader (Z)

Translational Molecular Neuroscience Group, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Martin Graf (M)

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.

Mark Burcin (M)

Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Basel, Switzerland.

Carl-Fredrik Mandenius (CF)

Division of Biotechnology, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, Sweden.

James A Ross (JA)

Tissue Injury and Repair Group, University of Edinburgh, Edinburgh, UK. j.a.ross@ed.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Photométrie › Mesures de luminescence › Fluorimétrie › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Techniques d'investigation › Tests de criblage à haut débit › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Microtechnologie › Microfluidique › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Cell-Based Assays Using Differentiated Human...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Cell-Based Assays Using Differentiated Human...