Systems pharmacogenomics - gene, disease, drug and placebo interactions: a case study in COMT.
Journal
Pharmacogenomics
ISSN: 1744-8042
Titre abrégé: Pharmacogenomics
Pays: England
ID NLM: 100897350
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
entrez:
25
5
2019
pubmed:
28
5
2019
medline:
14
4
2020
Statut:
ppublish
Résumé
Disease, drugs and the placebos used as comparators are inextricably linked in the methodology of the double-blind, randomized controlled trial. Nonetheless, pharmacogenomics, the study of how individuals respond to drugs based on genetic substrate, focuses primarily on the link between genes and drugs, while the link between genes and disease is often overlooked and the link between genes and placebos is largely ignored. Herein, we use the example of the enzyme catechol-O-methyltransferase to examine the hypothesis that genes can function as pharmacogenomic hubs across system-wide regulatory processes that, if perturbed in andomized controlled trials, can have primary and combinatorial effects on drug and placebo responses.
Identifiants
pubmed: 31124409
doi: 10.2217/pgs-2019-0001
pmc: PMC6563236
doi:
Substances chimiques
Biomarkers, Pharmacological
0
COMT protein, human
EC 2.1.1.6
Catechol O-Methyltransferase
EC 2.1.1.6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
529-551Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL130625
Pays : United States
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