Protective effect of Glycyrrhiza glabra roots extract on bone mineral density of ovariectomized rats.
Journal
BioMedicine
ISSN: 2211-8020
Titre abrégé: Biomedicine (Taipei)
Pays: China (Republic : 1949- )
ID NLM: 101611451
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
23
02
2019
accepted:
09
03
2019
entrez:
25
5
2019
pubmed:
28
5
2019
medline:
28
5
2019
Statut:
ppublish
Résumé
The aim of this study was to evaluate the potential effect of the methanolic extract of plant Glycyrrhiza glabra roots on bone mineral density and femoral bone strength of ovariectomized rats. Thirty 10-month-old Wistar rats were randomly separated into three groups of ten, Control, Ovariectomy and Ovariectomy-plus-Glycyrrhiza in their drinking water. Total and proximal tibial bone mineral density was measured in all groups before ovariectomy (baseline) and after 3 and 6 months post ovariectomy. Three-point-bending of the femurs and uterine weight and histology were examined at the end of the study. No significant difference was noted in bone density percentage change of total tibia from baseline to 3 months between Control and Ovariectomy-plus-Glycyrrhiza groups (+5.31% ± 4.75 and +3.30% ± 6.31 respectively, P = non significant), and of proximal tibia accordingly (+5.58% ± 6.92 and +2.61% ± 13.62, P = non significant) demonstrating a strong osteoprotective effect. There was notable difference in percentage change of total tibia from baseline to 6 months between groups Ovariectomy and Ovariectomy-plus-Glycyrrhiza (-13.03% ± 5.11 and -0.84% ± 7.63 respectively, P < 0.005), and of proximal tibia accordingly (-27.9% ± 3.69 and -0.81% ± 14.85 respectively, P < 0.001), confirming the protective effect of Glycyrrhiza glabra extract in preserving bone density of the Ovariectomy-plus-Glycyrrhiza group. Three-point-bending did not reveal any statistically significant difference between Ovariectomy and Ovariectomy-plus-Glycyrrhiza groups. Uterine weights of the Ovariectomy-plus-Glycyrrhiza group ranged between the other two groups with no statistically significant difference to each. Glycyrrhiza glabra root extract notably protected tibial bone mineral density loss in Ovariectomy-plus-Glycyrrhiza rats in comparison with ovariectomized rats, but did not improve biomechanical strength.
Identifiants
pubmed: 31124454
doi: 10.1051/bmdcn/2019090208
pii: bmdcn2019090208
pmc: PMC6533940
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8Informations de copyright
© Author(s) 2019. This article is published with open access by China Medical University.
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