On the use of a micro freeze-dryer for the investigation of the primary drying stage of a freeze-drying process.
Freeze-drying
Mathematical modeling
Micro freeze-dryer
Pharmaceuticals
Processing
Journal
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
ISSN: 1873-3441
Titre abrégé: Eur J Pharm Biopharm
Pays: Netherlands
ID NLM: 9109778
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
21
01
2019
revised:
03
04
2019
accepted:
21
05
2019
pubmed:
28
5
2019
medline:
26
11
2019
entrez:
25
5
2019
Statut:
ppublish
Résumé
This paper deals with the use of a small-scale freeze-dryer, where very few vials are loaded (e.g. 19, each 10 mL, or 7, each 20 mL), for freeze-drying cycle investigation. The system has a metallic ring surrounding the batch of vials, in contact with the external ones, and its temperature is manipulated independently from that of the shelf on the basis of the temperature of the product measured by thermocouples in some vials of the batch. The experimental study was carried out using two sucrose solutions (5% and 10% w/w), aiming to verify the homogeneity of the batch. Both product temperature and the weight loss after 6 h from the onset of the primary drying stage were selected as key parameters. Experiments were carried out according to a 2
Identifiants
pubmed: 31125719
pii: S0939-6411(19)30074-8
doi: 10.1016/j.ejpb.2019.05.019
pii:
doi:
Substances chimiques
Solutions
0
Sucrose
57-50-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121-129Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.