Associations of AD Biomarkers and Cognitive Performance with Nutritional Status: The NUDAD Project.
Aged
Alzheimer Disease
/ cerebrospinal fluid
Amyloid beta-Peptides
/ cerebrospinal fluid
Apolipoprotein E4
/ genetics
Biomarkers
/ cerebrospinal fluid
Body Composition
Body Mass Index
Case-Control Studies
Cognition
Cognitive Dysfunction
/ cerebrospinal fluid
Cross-Sectional Studies
Female
Humans
Male
Malnutrition
/ physiopathology
Middle Aged
Netherlands
Nutritional Status
Peptide Fragments
/ cerebrospinal fluid
Phosphorylation
Prospective Studies
Risk Factors
Waist Circumference
tau Proteins
/ cerebrospinal fluid
Alzheimer’s disease
body composition
malnutrition
mild cognitive impairment
older adults
subjective cognitive decline
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
23 May 2019
23 May 2019
Historique:
received:
09
05
2019
revised:
15
05
2019
accepted:
21
05
2019
entrez:
26
5
2019
pubmed:
28
5
2019
medline:
28
12
2019
Statut:
epublish
Résumé
As malnutrition is common in patients with Alzheimer's disease (AD), we evaluated nutritional status and body composition of patients with AD, mild cognitive impairment (MCI) and controls, and studied associations of AD biomarkers and cognitive performance with nutritional status and body composition. We included 552 participants, of which 198 patients had AD, 135 patients had MCI and 219 controls. We assessed nutritional status (mini nutritional assessment (MNA)) and body composition (body mass index (BMI), fat-free mass (FFM) and waist circumference). Linear regression analyses (adjusted for age, gender and education where appropriate) were applied to test associations of AD biomarkers and cognitive performance on five domains with nutritional parameters (dependent). Patients with MCI and AD had a lower BMI and MNA score than controls. Worse performance in all cognitive domains was associated with lower MNA score, but not with body composition. AD biomarkers were associated with MNA score, BMI and waist circumference, and associations with MNA score remained after adjustment for cognitive performance. Both AD biomarkers and cognitive performance were associated with nutritional status, associations with AD biomarkers remained after adjustment for cognition. Our data suggest that malnutrition is not only related to impaired cognition but also to AD pathology.
Identifiants
pubmed: 31126170
pii: nu11051161
doi: 10.3390/nu11051161
pmc: PMC6566264
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Apolipoprotein E4
0
Biomarkers
0
MAPT protein, human
0
Peptide Fragments
0
amyloid beta-protein (1-42)
0
tau Proteins
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 057-14-004
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