Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.
Animals
Autophagy
/ drug effects
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
/ drug effects
Binding Sites
Cells, Cultured
Circadian Clocks
/ drug effects
Circadian Rhythm
/ drug effects
Energy Metabolism
/ drug effects
Gene Expression Regulation
HEK293 Cells
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nuclear Receptor Subfamily 1, Group D, Member 1
/ genetics
Nutrients
/ pharmacology
Transcription Factors
/ drug effects
MiT‐TFE
REV‐ERBα
circadian rhythm
gene oscillation
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
17 06 2019
17 06 2019
Historique:
received:
10
12
2018
revised:
03
04
2019
accepted:
15
04
2019
pubmed:
28
5
2019
medline:
3
1
2020
entrez:
26
5
2019
Statut:
ppublish
Résumé
Autophagy and energy metabolism are known to follow a circadian pattern. However, it is unclear whether autophagy and the circadian clock are coordinated by common control mechanisms. Here, we show that the oscillation of autophagy genes is dependent on the nutrient-sensitive activation of TFEB and TFE3, key regulators of autophagy, lysosomal biogenesis, and cell homeostasis. TFEB and TFE3 display a circadian activation over the 24-h cycle and are responsible for the rhythmic induction of genes involved in autophagy during the light phase. Genetic ablation of TFEB and TFE3 in mice results in deregulated autophagy over the diurnal cycle and altered gene expression causing abnormal circadian wheel-running behavior. In addition, TFEB and TFE3 directly regulate the expression of
Identifiants
pubmed: 31126958
pii: embj.2018101347
doi: 10.15252/embj.2018101347
pmc: PMC6576167
pii:
doi:
Substances chimiques
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Nr1d1 protein, mouse
0
Nuclear Receptor Subfamily 1, Group D, Member 1
0
Tcfeb protein, mouse
0
Transcription Factors
0
Tcfe3 protein, mouse
136896-33-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NINDS NIH HHS
ID : R01 NS078072
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083092
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 The Authors.
Références
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W551-4
pubmed: 16845068
Mol Ther. 2003 Nov;8(5):846-52
pubmed: 14599819
Int J Biochem Cell Biol. 2016 Sep;78:31-42
pubmed: 27373683
Nucleic Acids Res. 2019 Jan 8;47(D1):D853-D858
pubmed: 30407534
Cell Metab. 2017 Jan 10;25(1):182-196
pubmed: 28011087
Science. 2015 Jun 26;348(6242):1488-92
pubmed: 26044300
Nat Med. 2013 Aug;19(8):1039-46
pubmed: 23852339
Mol Endocrinol. 2008 Aug;22(8):1797-811
pubmed: 18511497
Science. 2000 Sep 29;289(5488):2344-7
pubmed: 11009419
Nature. 2002 Aug 1;418(6897):534-9
pubmed: 12152080
EMBO J. 2011 Sep 06;30(22):4642-51
pubmed: 21897364
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
Annu Rev Cell Dev Biol. 2001;17:215-53
pubmed: 11687489
Autophagy. 2016 Aug 2;12(8):1292-309
pubmed: 27171500
Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R271-7
pubmed: 16987893
Science. 2010 Dec 3;330(6009):1349-54
pubmed: 21127246
Science. 2009 Jul 24;325(5939):473-7
pubmed: 19556463
J Virol. 1999 May;73(5):3994-4003
pubmed: 10196295
Elife. 2013 Apr 09;2:e00426
pubmed: 23580255
Sci Signal. 2012 Jun 12;5(228):ra42
pubmed: 22692423
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11592-9
pubmed: 25082895
Gastroenterology. 2008 Aug;135(2):689-98
pubmed: 18565334
Nature. 2012 Mar 29;485(7396):62-8
pubmed: 22460951
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4477-82
pubmed: 11930005
Cell Rep. 2016 Oct 25;17(5):1453-1461
pubmed: 27783956
Nature. 2018 Jan 18;553(7688):351-355
pubmed: 29320480
Science. 2000 Dec 1;290(5497):1717-21
pubmed: 11099404
Science. 2007 Dec 14;318(5857):1786-9
pubmed: 18006707
Cell Metab. 2011 Feb 2;13(2):125-37
pubmed: 21284980
Science. 2011 Mar 11;331(6022):1315-9
pubmed: 21393543
Nat Cell Biol. 2013 Jun;15(6):647-58
pubmed: 23604321
Nucleic Acids Res. 2016 Jan 4;44(D1):D7-19
pubmed: 26615191
EMBO J. 2012 Mar 7;31(5):1095-108
pubmed: 22343943
J Biol Chem. 2003 Sep 26;278(39):37672-80
pubmed: 12821652
Genes Dev. 2012 Apr 1;26(7):657-67
pubmed: 22474260
Science. 2017 Jun 16;356(6343):1188-1192
pubmed: 28619945
Trends Endocrinol Metab. 2010 Jul;21(7):402-10
pubmed: 20303779
Hum Mol Genet. 2011 Oct 1;20(19):3852-66
pubmed: 21752829
Development. 1998 Dec;125(23):4607-16
pubmed: 9806910
Methods Mol Med. 2002;69:371-88
pubmed: 11987790
Autophagy. 2012 Jun;8(6):903-14
pubmed: 22576015
Science. 2001 Jan 19;291(5503):490-3
pubmed: 11161204
Cell. 2013 Apr 11;153(2):335-47
pubmed: 23582324
Genes Dev. 2000 Dec 1;14(23):2950-61
pubmed: 11114885
Acta Histochem Suppl. 1976;16:109-15
pubmed: 830002
Nat Methods. 2015 Oct;12(10):982-8
pubmed: 26322839
Brief Bioinform. 2008 Jul;9(4):326-32
pubmed: 18436575
Cell Metab. 2015 Dec 1;22(6):1009-19
pubmed: 26387865
Nature. 2012 Mar 29;485(7396):123-7
pubmed: 22460952
Diabetes. 2006 Apr;55(4):962-70
pubmed: 16567517
Nat Cell Biol. 2015 Mar;17(3):288-99
pubmed: 25720963
Sci Signal. 2014 Jan 21;7(309):ra9
pubmed: 24448649
J Cell Biol. 1975 Mar;64(3):608-21
pubmed: 1171105
Genome Biol. 2008;9(9):R137
pubmed: 18798982
Mol Cell Biol. 2008 Apr;28(7):2213-20
pubmed: 18227153
EMBO Mol Med. 2017 May;9(5):605-621
pubmed: 28283651
Science. 2011 Jun 17;332(6036):1429-33
pubmed: 21617040
Nat Rev Mol Cell Biol. 2013 May;14(5):283-96
pubmed: 23609508
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943