Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival.
Carcinoma, Non-Small-Cell Lung
/ metabolism
Cell Line, Tumor
Cell Proliferation
/ drug effects
ErbB Receptors
/ antagonists & inhibitors
Erlotinib Hydrochloride
/ pharmacology
Gene Expression Regulation
/ drug effects
Glycolysis
Humans
Lung Neoplasms
/ metabolism
Mutation
Phosphofructokinase-2
/ antagonists & inhibitors
Phosphorylation
RNA Interference
RNA, Small Interfering
/ metabolism
Signal Transduction
/ drug effects
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
PFKFB3
epidermal growth factor (EGF)
epidermal growth factor receptor (EGFR)
erlotinib
glycolysis
lung cancer
metabolism
small molecule antagonist
tumorigenesis
tyrosine kinase inhibitor
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
05 07 2019
05 07 2019
Historique:
received:
28
01
2019
revised:
20
05
2019
pubmed:
28
5
2019
medline:
11
3
2020
entrez:
26
5
2019
Statut:
ppublish
Résumé
Constitutive activation of the epidermal growth factor receptor (EGFR) because of somatic mutations of the
Identifiants
pubmed: 31126985
pii: S0021-9258(20)31844-5
doi: 10.1074/jbc.RA119.007784
pmc: PMC6615683
doi:
Substances chimiques
RNA, Small Interfering
0
Erlotinib Hydrochloride
DA87705X9K
PFKFB3 protein, human
EC 2.7.1.105
Phosphofructokinase-2
EC 2.7.1.105
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10530-10543Informations de copyright
© 2019 Lypova et al.
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