Prenatal and recent methylmercury exposure and heart rate variability in young adults: the Seychelles Child Development Study.
Journal
Neurotoxicology and teratology
ISSN: 1872-9738
Titre abrégé: Neurotoxicol Teratol
Pays: United States
ID NLM: 8709538
Informations de publication
Date de publication:
Historique:
received:
10
08
2018
revised:
22
03
2019
accepted:
21
05
2019
pubmed:
28
5
2019
medline:
15
5
2020
entrez:
26
5
2019
Statut:
ppublish
Résumé
Epidemiologic evidence of an adverse association between exposure to methylmercury (MeHg) from consuming fish and heart rate variability (HRV) is inconclusive. We aimed to evaluate MeHg exposure in relation to HRV parameters in a large cohort of young adults from a high fish consuming population in the Republic of Seychelles. Main Cohort participants in the Seychelles Child Development Study were evaluated at a mean age of 19 years. Prenatal MeHg exposure was determined in maternal hair growing during pregnancy and recent exposure in participant's hair taken at the evaluation. The evaluation consisted of short (~2 h) and long (overnight) Holter recordings obtained in 514 and 203 participants, respectively. Multivariable analyses examined the association of prenatal and recent MeHg exposure (in separate models) with time-domain and frequency-domain HRV parameters in different physiologic circumstances: supine position, standing position, mental stress when undergoing a mathematics test, sleep, and long recording. Prenatal MeHg exposure was not associated with any of the 23 HRV parameters studied after adjustment for multiplicity. The recent MeHg showed a trend toward significance only for few variables in the primary model. However, after additional adjustment for activity levels, polyunsaturated fatty acids, and multiplicity none were significant after a Bonferroni adjustment. In conclusion, prenatal and recent MeHg exposure had no consistent pattern of associations to support the hypothesis that they are adversely associated with heart rate variability in this study population that consumes large amounts of fish.
Identifiants
pubmed: 31128243
pii: S0892-0362(18)30106-5
doi: 10.1016/j.ntt.2019.106810
pmc: PMC6642841
mid: NIHMS1531979
pii:
doi:
Substances chimiques
Methylmercury Compounds
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
106810Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES001247
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES008442
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007271
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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