Association between exhaled nitric oxide and nasal polyposis in severe asthma.
Aged
Asthma
/ diagnosis
Biomarkers
/ metabolism
Eosinophils
Exhalation
Female
Humans
Italy
/ epidemiology
Lung
/ physiopathology
Male
Middle Aged
Nasal Polyps
/ complications
Neutrophils
Nitric Oxide
/ analysis
Paranasal Sinuses
/ diagnostic imaging
Respiratory Function Tests
/ methods
Severity of Illness Index
Tomography, X-Ray Computed
/ methods
Biomarkers
Breath
Disability
Exhaled
Lung
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
04
01
2019
revised:
09
03
2019
accepted:
21
04
2019
entrez:
27
5
2019
pubmed:
28
5
2019
medline:
28
4
2020
Statut:
ppublish
Résumé
Although several contributions exist on the role of fractional exhaled NO (FeNO) in diagnosis and management of asthma, no studies have analysed the association between FeNO in patients with severe asthma and nasal polyposis. We investigated the potential association between FeNO and the presence of nasal polyps in patients affected by severe asthma. Study population included 93 severe asthmatic adult patients consecutively enrolled from four Italian specialist clinic centres from 2015 to 2018. In these patients lung function, asthma control, FeNO, blood eosinophils and CT scan of paranasal sinuses were evaluated. Nasal polyposis was observed in 28 patients (30%). Among univariate predictors (lower BMI, higher FeNO, eosinophil and neutrophil count), recursive partitioning analysis identified as best predictors of nasal polyposis high values of eosinophil count (≥6.5% or >420 cells/mm Our results show that FeNO might improve to detect nasal polyposis in patients with severe asthma and a low level of blood eosinophils counts, identifying individuals with high susceptibility to this condition.
Sections du résumé
BACKGROUND
Although several contributions exist on the role of fractional exhaled NO (FeNO) in diagnosis and management of asthma, no studies have analysed the association between FeNO in patients with severe asthma and nasal polyposis.
AIM
We investigated the potential association between FeNO and the presence of nasal polyps in patients affected by severe asthma.
METHODS
Study population included 93 severe asthmatic adult patients consecutively enrolled from four Italian specialist clinic centres from 2015 to 2018. In these patients lung function, asthma control, FeNO, blood eosinophils and CT scan of paranasal sinuses were evaluated.
RESULTS
Nasal polyposis was observed in 28 patients (30%). Among univariate predictors (lower BMI, higher FeNO, eosinophil and neutrophil count), recursive partitioning analysis identified as best predictors of nasal polyposis high values of eosinophil count (≥6.5% or >420 cells/mm
CONCLUSIONS
Our results show that FeNO might improve to detect nasal polyposis in patients with severe asthma and a low level of blood eosinophils counts, identifying individuals with high susceptibility to this condition.
Identifiants
pubmed: 31128605
pii: S0954-6111(19)30138-6
doi: 10.1016/j.rmed.2019.04.017
pii:
doi:
Substances chimiques
Biomarkers
0
Nitric Oxide
31C4KY9ESH
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
20-24Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.