Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging.
Cluster analysis
MCI
Mild cognitive impairment
Neuropsychology
Subtle cognitive impairment
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
28
09
2018
revised:
12
03
2019
accepted:
25
03
2019
pubmed:
28
5
2019
medline:
11
7
2020
entrez:
27
5
2019
Statut:
ppublish
Résumé
We evaluated whether incident mild cognitive impairment (MCI) subtypes could be empirically derived in the Mayo Clinic Study of Aging. We performed cluster analysis on neuropsychological data from 506 participants with incident MCI. The 3-cluster solution resulted in (1) amnestic, (2) dysexecutive, (3) dysnomic subtypes. The 4-cluster solution produced these same three groups and a fourth group with subtle cognitive impairment (SCI). The SCI cluster was a subset of the amnestic cluster and distinct from well-matched cognitively unimpaired participants based on memory and global z-score area under the receiver operating characteristic curve analyses and probability of progression to MCI/dementia. We empirically identified three neuropsychological subtypes of MCI that share some features with MCI subtypes identified in the Alzheimer's Disease Neuroimaging Initiative. The fourth subtype with SCI in the Mayo Clinic Study of Aging differed from the fourth cluster-derived normal group in Alzheimer's Disease Neuroimaging Initiative and could represent a group to target with early interventions.
Identifiants
pubmed: 31128864
pii: S1552-5260(19)30089-5
doi: 10.1016/j.jalz.2019.03.014
pmc: PMC6646057
mid: NIHMS1530309
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
878-887Subventions
Organisme : NIA NIH HHS
ID : R01 AG034676
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049810
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG006786
Pays : United States
Informations de copyright
Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Références
J Lipid Res. 1990 Mar;31(3):545-8
pubmed: 2341813
Am J Geriatr Psychiatry. 2014 Jul;22(7):670-81
pubmed: 23831172
Neurology. 2012 Oct 9;79(15):1599-606
pubmed: 23019262
Neuroepidemiology. 2008;30(1):58-69
pubmed: 18259084
Arch Neurol. 1991 Jul;48(7):725-8
pubmed: 1859300
Dement Geriatr Cogn Disord. 2013;36(1-2):1-19
pubmed: 23651945
Neurology. 2016 Nov 15;87(20):2108-2116
pubmed: 27760874
Br J Psychiatry. 1968 Jul;114(512):797-811
pubmed: 5662937
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Alzheimers Dement. 2015 Apr;11(4):415-24
pubmed: 24857234
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Gerontol. 1982 May;37(3):323-9
pubmed: 7069156
Neurology. 2018 Jan 16;90(3):126-135
pubmed: 29282327
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
J Int Neuropsychol Soc. 2009 Nov;15(6):906-14
pubmed: 19891820
Neurology. 2017 Jun 6;88(23):2225-2232
pubmed: 28490651
Stat Med. 2006 Feb 28;25(4):559-73
pubmed: 16217835
Neurology. 2014 Jan 28;82(4):317-25
pubmed: 24353333
Neurology. 2010 Jan 19;74(3):201-9
pubmed: 20042704
Clin Neuropsychol. 2013;27(8):1247-64
pubmed: 24041121
Alzheimer Dis Assoc Disord. 2016 Oct-Dec;30(4):324-330
pubmed: 26908276
J Am Med Dir Assoc. 2016 Oct 1;17(10):943-8
pubmed: 27502450
Am J Geriatr Psychiatry. 2009 May;17(5):368-75
pubmed: 19390294
Neuropsychology. 1999 Jan;13(1):121-7
pubmed: 10067783
Neurology. 2012 Oct 9;79(15):1591-8
pubmed: 23019264
Neurology. 2015 Nov 10;85(19):1712-21
pubmed: 26453643
J Int Neuropsychol Soc. 2013 Jul;19(6):635-45
pubmed: 23552486
J Intern Med. 2004 Sep;256(3):240-6
pubmed: 15324367
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
J Alzheimers Dis. 2014;42(1):275-89
pubmed: 24844687
Stat Med. 2006 Feb 28;25(4):591-602
pubmed: 16143965
J Int Neuropsychol Soc. 2010 Jan;16(1):84-93
pubmed: 19887015
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248