4-Locus high-resolution HLA allele and haplotype frequencies in Amerindians from Costa Rica.
Admixture
Ancestry
Costa Rica
Ethnicity
Frequencies
Human leukocyte antigen
Native American
Population
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
23
04
2019
revised:
06
05
2019
accepted:
10
05
2019
pubmed:
28
5
2019
medline:
28
5
2019
entrez:
27
5
2019
Statut:
ppublish
Résumé
A total of 125 Costa Ricans of Amerindian descent were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, and -DRB1 using sequence-based typing methods. The respective allele and extended haplotype frequencies, as well as Hardy-Weinberg proportions were calculated. The most frequent extended haplotype identified was A*24:02:01-B*40:02:01-C*03:05-DRB1*04:07:01G, with an estimated frequency of 8.26%. A deviation from Hardy-Weinberg Equilibrium was detected at the DRB1 locus (p = 0.099). The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Costa Rica Amerindians" and the identifier AFN3608.
Identifiants
pubmed: 31128907
pii: S0198-8859(19)30454-9
doi: 10.1016/j.humimm.2019.05.008
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
409-410Informations de copyright
Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.