The use of iPSC technology for modeling Autism Spectrum Disorders.
Autism Spectrum Disorders
Brain cells
Brain organoid
Disease modeling
Stem cells
iPSC
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
30
10
2018
revised:
31
03
2019
accepted:
22
05
2019
pubmed:
28
5
2019
medline:
25
3
2020
entrez:
27
5
2019
Statut:
ppublish
Résumé
Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental disorders that influence social skills, involving communication, interaction, and behavior, usually with repetitive and restrictive manners. Due to the variety of genes involved in ASDs and several possible environmental factors influence, there is still no answer to what really causes syndromic and non-syndromic types of ASDs, usually affecting each individual in a unique way. However, we know that the mechanism underlying ASDs involves brain functioning. The human brain is a complex structure composed of close to 100 billion cells, which is a big challenge to study counting just with post mortem tissue investigation or genetic approaches. Therefore, human induced pluripotent stem cells (iPSC) technology has been used as a tool to produce viable cells for understanding a working brain. Taking advantage of patient-derived stem cells, researchers are now able to generate neurons, glial cells and brain organoids in vitro to model ASDs. In this review we report data from different studies showing how iPSCs have been a critical tool to study the different phenotypes of ASDs.
Identifiants
pubmed: 31129084
pii: S0969-9961(19)30134-2
doi: 10.1016/j.nbd.2019.104483
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104483Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.