Aberration methylation of miR-34b was involved in regulating vascular calcification by targeting Notch1.
Animals
Cell Differentiation
CpG Islands
DNA (Cytosine-5-)-Methyltransferases
/ metabolism
DNA Methylation
DNA Methyltransferase 3A
Humans
Male
Mice, Inbred C57BL
MicroRNAs
/ metabolism
Muscle, Smooth, Vascular
/ metabolism
Myocytes, Smooth Muscle
/ metabolism
Osteoblasts
Receptor, Notch1
/ metabolism
Renal Artery
/ metabolism
Uremia
/ metabolism
Vascular Calcification
/ metabolism
Notch1
methylation
miR-34b
vascular calcification
vascular smooth muscle cells
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
25 05 2019
25 05 2019
Historique:
received:
01
02
2019
accepted:
12
05
2019
pubmed:
28
5
2019
medline:
18
6
2020
entrez:
27
5
2019
Statut:
ppublish
Résumé
Vascular calcification is one of the most important factors for cardiovascular and all-cause mortality in patients with end-stage renal diseases (ESRD). The current study was aimed to investigate the function and mechanisms of miR-34b on the calcification of vascular smooth muscle cells (VSMCs) both
Identifiants
pubmed: 31129659
doi: 10.18632/aging.101973
pii: 101973
pmc: PMC6555467
doi:
Substances chimiques
DNMT3A protein, human
0
Dnmt3a protein, mouse
0
MIRN34 microRNA, human
0
MIRN34a microRNA, mouse
0
MicroRNAs
0
Notch1 protein, mouse
0
Receptor, Notch1
0
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
DNA Methyltransferase 3A
EC 2.1.1.37
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3182-3197Références
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