Magnetic-resonance-guided focused ultrasound treatment of non-spinal osteoid osteoma in children: multicentre experience.
Adolescents
Bone
Children
Magnetic-resonance-guided focused ultrasound
Osteoid osteoma
Journal
Pediatric radiology
ISSN: 1432-1998
Titre abrégé: Pediatr Radiol
Pays: Germany
ID NLM: 0365332
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
12
10
2018
accepted:
13
05
2019
revised:
05
03
2019
pubmed:
28
5
2019
medline:
1
7
2020
entrez:
27
5
2019
Statut:
ppublish
Résumé
Osteoid osteoma is a benign and painful musculoskeletal tumour that usually affects children. Current standard treatment is CT-guided radiofrequency ablation, a minimally invasive percutaneous procedure, with clinical success rates ranging between 85% and 98%. Though minimally invasive, however, this type of procedure is not free from complications. To investigate the efficacy and safety of magnetic resonance (MR)-guided focused ultrasound (MRgFUS), a needleless procedure of thermal ablation employed in the treatment of non-spinal osteoid osteoma in paediatric patients. We report the results of 33 procedures of ablation of osteoid osteoma performed with MRgFUS in three university hospitals. To ablate a lesion on the bone surface, MRgFUS employs the ultrasound energy transduced along the soft tissue. The follow-up studies lasted 24 months and were performed combining clinical and imaging data. Mean age of the children was 13.8 years. The clinical outcome showed a primary success of 97%. One case alone was submitted to repeat treatment because the first one failed (secondary success). No major or minor complications were recorded. During the investigation time, no relapse of symptomatology or delayed complications were observed. Although our study is preliminary and limited by a low number of patients, our data show that MRgFUS is effective. This suggests that it might be useful as the first-line treatment in paediatric patients with osteoid osteoma.
Sections du résumé
BACKGROUND
Osteoid osteoma is a benign and painful musculoskeletal tumour that usually affects children. Current standard treatment is CT-guided radiofrequency ablation, a minimally invasive percutaneous procedure, with clinical success rates ranging between 85% and 98%. Though minimally invasive, however, this type of procedure is not free from complications.
OBJECTIVE
To investigate the efficacy and safety of magnetic resonance (MR)-guided focused ultrasound (MRgFUS), a needleless procedure of thermal ablation employed in the treatment of non-spinal osteoid osteoma in paediatric patients.
MATERIALS AND METHODS
We report the results of 33 procedures of ablation of osteoid osteoma performed with MRgFUS in three university hospitals. To ablate a lesion on the bone surface, MRgFUS employs the ultrasound energy transduced along the soft tissue. The follow-up studies lasted 24 months and were performed combining clinical and imaging data.
RESULTS
Mean age of the children was 13.8 years. The clinical outcome showed a primary success of 97%. One case alone was submitted to repeat treatment because the first one failed (secondary success). No major or minor complications were recorded. During the investigation time, no relapse of symptomatology or delayed complications were observed.
CONCLUSION
Although our study is preliminary and limited by a low number of patients, our data show that MRgFUS is effective. This suggests that it might be useful as the first-line treatment in paediatric patients with osteoid osteoma.
Identifiants
pubmed: 31129699
doi: 10.1007/s00247-019-04426-0
pii: 10.1007/s00247-019-04426-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1209-1216Références
J Pediatr Orthop B. 2003 Jul;12(4):244-52
pubmed: 12821840
Radiol Med. 2014 Jul;119(7):470-5
pubmed: 24894922
Pediatr Radiol. 2006 Feb;36(2):115-8
pubmed: 16315060
Med Oncol. 2017 Apr;34(4):55
pubmed: 28244018
J Pediatr. 2017 Nov;190:222-228.e1
pubmed: 28823554
Radiology. 2017 Oct;285(1):186-196
pubmed: 28590796
Radiology. 2014 Oct;273(1):241-60
pubmed: 24927329
Br J Radiol. 2016;89(1057):20150369
pubmed: 26235144
Diagn Interv Radiol. 2013 Jul-Aug;19(4):330-9
pubmed: 23491835
Radiology. 2003 Oct;229(1):171-5
pubmed: 12944597
Br J Radiol. 2016;89(1057):20150358
pubmed: 26607640
J Bone Joint Surg Am. 2014 May 7;96(9):743-51
pubmed: 24806011
Br J Radiol. 2016 Oct;89(1066):20150356
pubmed: 27197743
Pain. 2006 Nov;125(1-2):143-57
pubmed: 16777328
Eur Radiol. 2016 Aug;26(8):2472-81
pubmed: 26612546
Cardiovasc Intervent Radiol. 2014 Dec;37(6):1530-9
pubmed: 24337349
Med Oncol. 2017 Apr;34(4):53
pubmed: 28236103
Int J Hyperthermia. 2018 Feb;34(1):49-58
pubmed: 28540807
J Pediatr Orthop. 2008 Mar;28(2):265-70
pubmed: 18388727
AJR Am J Roentgenol. 1998 Mar;170(3):609-14
pubmed: 9490939
Yale J Biol Med. 2001 Jan-Feb;74(1):1-8
pubmed: 11249234
Radiology. 2013 May;267(2):514-21
pubmed: 23392424
Int J Hyperthermia. 2018 May;34(3):321-327
pubmed: 28597707
J Bone Joint Surg Br. 1999 Sep;81(5):814-20
pubmed: 10530842