Effects of copaiba oil on dermonecrosis induced by
Loxosceles intermedia
copaiba oil
skin lesion
topical treatment
venom
Journal
The journal of venomous animals and toxins including tropical diseases
ISSN: 1678-9199
Titre abrégé: J Venom Anim Toxins Incl Trop Dis
Pays: Brazil
ID NLM: 101201501
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
08
2018
accepted:
01
02
2019
entrez:
28
5
2019
pubmed:
28
5
2019
medline:
28
5
2019
Statut:
epublish
Résumé
Accidents caused by spiders of the genus Cutaneous lesions were induced on the backs of rabbits by intradermal injection of Compared to the control group, the platelet count was reduced significantly in all groups inoculated with venom, accompanied by a decreased number of heterophils in the blood. The minimum necrotic dose (MND) was defined as 2.4 μg/kg. Topical treatment with copaiba oil demonstrated a differentiated healing profile: large skin lesions were observed 10 days after venom inoculation, whereas formation of a thick crust, without scarring was observed 30 days after venom inoculation. Histopathological analysis showed no significant difference after treatment. Nevertheless, the copaiba oil treatment induced a collagen distribution similar to control skin, in marked contrast to the group that received only the spider venom injection. We conclude that copaiba oil may interfere in the healing process and thus propose it as a possible topical treatment for cutaneous lesions induced by
Sections du résumé
BACKGROUND
BACKGROUND
Accidents caused by spiders of the genus
METHODS
METHODS
Cutaneous lesions were induced on the backs of rabbits by intradermal injection of
RESULTS
RESULTS
Compared to the control group, the platelet count was reduced significantly in all groups inoculated with venom, accompanied by a decreased number of heterophils in the blood. The minimum necrotic dose (MND) was defined as 2.4 μg/kg. Topical treatment with copaiba oil demonstrated a differentiated healing profile: large skin lesions were observed 10 days after venom inoculation, whereas formation of a thick crust, without scarring was observed 30 days after venom inoculation. Histopathological analysis showed no significant difference after treatment. Nevertheless, the copaiba oil treatment induced a collagen distribution similar to control skin, in marked contrast to the group that received only the spider venom injection.
CONCLUSIONS
CONCLUSIONS
We conclude that copaiba oil may interfere in the healing process and thus propose it as a possible topical treatment for cutaneous lesions induced by
Identifiants
pubmed: 31131009
doi: 10.1590/1678-9199-JVATITD-1493-18
pmc: PMC6521710
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e149318Déclaration de conflit d'intérêts
Competing interests: The authors declare that they have no competing interests.
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