First report of two successive deletions on chromosome 15q13 cytogenetic bands in a boy and girl: additional data to 15q13.3 syndrome with a report of high IQ patient.

15q13.3 syndrome And learning disability CHRNA7 Cognitive impairment Consecutive deletions High IQ Hyperactivity

Journal

Molecular cytogenetics
ISSN: 1755-8166
Titre abrégé: Mol Cytogenet
Pays: England
ID NLM: 101317942

Informations de publication

Date de publication:
2019
Historique:
received: 13 02 2019
accepted: 01 05 2019
entrez: 28 5 2019
pubmed: 28 5 2019
medline: 28 5 2019
Statut: epublish

Résumé

15q13.3 syndrome is associated with a wide spectrum of neurological disorders. Among a cohort of 150 neurodevelopmental cases, we identified two patients with two close proximity interstitial hemizygous deletions on chromosome 15q13. Using high-density microarrays, we characterized these deletions and their approximate breakpoints. The second deletion in both patients overlaps in a small area containing

Identifiants

pubmed: 31131027
doi: 10.1186/s13039-019-0432-6
pii: 432
pmc: PMC6525444
doi:

Types de publication

Journal Article

Langues

eng

Pagination

21

Déclaration de conflit d'intérêts

Competing interestsThe authors declare that they have no competing interests.

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Auteurs

Maysoon Alsagob (M)

1Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC: 03, Riyadh, 11211 Kingdom of Saudi Arabia.

Mustafa A Salih (MA)

2Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Muddathir H A Hamad (MHA)

2Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Yusra Al-Yafee (Y)

1Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC: 03, Riyadh, 11211 Kingdom of Saudi Arabia.

Jawaher Al-Zahrani (J)

1Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC: 03, Riyadh, 11211 Kingdom of Saudi Arabia.

Albandary Al-Bakheet (A)

1Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC: 03, Riyadh, 11211 Kingdom of Saudi Arabia.

Michael Nester (M)

3Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Nadia Sakati (N)

3Department of Neurosciences, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Salma M Wakil (SM)

1Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC: 03, Riyadh, 11211 Kingdom of Saudi Arabia.

Ali AlOdaib (A)

1Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC: 03, Riyadh, 11211 Kingdom of Saudi Arabia.

Dilek Colak (D)

4Department of Biostatistics, Epidemiology, and Scientific Computing, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Namik Kaya (N)

1Department of Genetics, King Faisal Specialist Hospital and Research Centre, MBC: 03, Riyadh, 11211 Kingdom of Saudi Arabia.
2Division of Pediatric Neurology, Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Classifications MeSH