In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine.
Adult
Biomarkers
/ blood
Blood Proteins
/ classification
Case-Control Studies
Chemokine CCL22
/ blood
Drugs, Chinese Herbal
/ therapeutic use
Elafin
/ blood
Female
Gene Expression
Humans
Interleukin-12 Subunit p40
/ blood
Male
Mass Spectrometry
Medicine, Chinese Traditional
/ methods
Metabolic Networks and Pathways
/ drug effects
Middle Aged
Principal Component Analysis
Protein Array Analysis
Proteome
/ classification
Proteomics
/ methods
Psoriasis
/ blood
Severity of Illness Index
Antibody Microarray
Biomarker
Data-Independent Acquisition Mass Spectrometry
Proteomics
Psoriasis
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
11
2018
accepted:
22
02
2019
entrez:
28
5
2019
pubmed:
28
5
2019
medline:
27
6
2020
Statut:
epublish
Résumé
Serum and plasma contain abundant biological information that reflect the body's physiological and pathological conditions and are therefore a valuable sample type for disease biomarkers. However, comprehensive profiling of the serological proteome is challenging due to the wide range of protein concentrations in serum.
Identifiants
pubmed: 31131048
doi: 10.7150/thno.31144
pii: thnov09p2475
pmc: PMC6526001
doi:
Substances chimiques
Biomarkers
0
Blood Proteins
0
CCL22 protein, human
0
Chemokine CCL22
0
Drugs, Chinese Herbal
0
Elafin
0
IL12B protein, human
0
Interleukin-12 Subunit p40
0
PI3 protein, human
0
Proteome
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2475-2488Déclaration de conflit d'intérêts
Competing Interests: The research group of T.G. is supported by Thermo Fisher, which provided access to mass spectrometry instrumentation.
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