Epidemiology of viral acute lower respiratory infections in a community-based cohort of rural north Indian children.
Journal
Journal of global health
ISSN: 2047-2986
Titre abrégé: J Glob Health
Pays: Scotland
ID NLM: 101578780
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
entrez:
28
5
2019
pubmed:
28
5
2019
medline:
7
6
2019
Statut:
ppublish
Résumé
In India, community-based acute lower respiratory infections (ALRI) burden studies are limited, hampering development of prevention and control strategies. We surveyed children <10 years old at home weekly from August 2012-August 2014, for cough, sore throat, rhinorrhoea, ear discharge, and shortness of breath. Symptomatic children were assessed for ALRI using World Health Organization definitions. Nasal and throat swabs were obtained from all ALRI cases and asymptomatic controls and tested using polymerase chain reaction for respiratory syncytial virus (RSV), human metapneumovirus (hMPV), parainfluenza viruses (PIV), and influenza viruses (IV). We estimated adjusted odds ratios (aOR) using logistic regression to calculate etiologic fractions (EF). We multiplied agent-specific ALRI incidence rates by EF to calculate the adjusted incidence as episodes per child-year. ALRI incidence was 0.19 (95% confidence interval (CI) = 0.18-0.20) episode per child-year. Association between virus and ALRI was strongest for RSV (aOR = 15.9; 95% CI = 7.3-34.7; EF = 94%) and least for IV (aOR = 4.6; 95% CI = 2.0-10.6; EF = 78%). Adjusted agent-specific ALRI incidences were RSV (0.03, 95% CI = 0.02-0.03), hMPV (0.02, 95% CI = 0.01-0.02), PIV (0.02, 95% CI = 0.01-0.02), and IV (0.01, 95% CI = 0.01-0.01) episode per child-year. ALRI among children in rural India was high; RSV was a significant contributor.
Sections du résumé
BACKGROUND
BACKGROUND
In India, community-based acute lower respiratory infections (ALRI) burden studies are limited, hampering development of prevention and control strategies.
METHODS
METHODS
We surveyed children <10 years old at home weekly from August 2012-August 2014, for cough, sore throat, rhinorrhoea, ear discharge, and shortness of breath. Symptomatic children were assessed for ALRI using World Health Organization definitions. Nasal and throat swabs were obtained from all ALRI cases and asymptomatic controls and tested using polymerase chain reaction for respiratory syncytial virus (RSV), human metapneumovirus (hMPV), parainfluenza viruses (PIV), and influenza viruses (IV). We estimated adjusted odds ratios (aOR) using logistic regression to calculate etiologic fractions (EF). We multiplied agent-specific ALRI incidence rates by EF to calculate the adjusted incidence as episodes per child-year.
RESULTS
RESULTS
ALRI incidence was 0.19 (95% confidence interval (CI) = 0.18-0.20) episode per child-year. Association between virus and ALRI was strongest for RSV (aOR = 15.9; 95% CI = 7.3-34.7; EF = 94%) and least for IV (aOR = 4.6; 95% CI = 2.0-10.6; EF = 78%). Adjusted agent-specific ALRI incidences were RSV (0.03, 95% CI = 0.02-0.03), hMPV (0.02, 95% CI = 0.01-0.02), PIV (0.02, 95% CI = 0.01-0.02), and IV (0.01, 95% CI = 0.01-0.01) episode per child-year.
CONCLUSIONS
CONCLUSIONS
ALRI among children in rural India was high; RSV was a significant contributor.
Identifiants
pubmed: 31131104
doi: 10.7189/jogh.09.010433
pii: jogh-09-010433
pmc: PMC6513504
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
010433Subventions
Organisme : NCIRD CDC HHS
ID : U01 IP000492
Pays : United States
Déclaration de conflit d'intérêts
Competing interests: The authors completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf and declare no conflicts of interest.
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