Selective Aerobic Oxygenation of Tertiary Allylic Alcohols with Molecular Oxygen.
allylic compounds
chemoselectivity
copper
oxygen
rearrangements
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
05 08 2019
05 08 2019
Historique:
received:
26
03
2019
revised:
30
04
2019
pubmed:
28
5
2019
medline:
28
5
2019
entrez:
28
5
2019
Statut:
ppublish
Résumé
Aerobic epoxidation of tertiary allylic alcohols remains a significant challenge. Reported here is an efficient and highly chemoselective copper-catalyzed epoxidation and semipinacol rearrangement reaction of tertiary allylic alcohols with molecular oxygen. The solvent 1,4-dioxane activates dioxygen, thereby precluding the addition of a sacrificial reductant.
Identifiants
pubmed: 31131518
doi: 10.1002/anie.201903690
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11028-11032Subventions
Organisme : the National Basic Research Program of China
ID : 2015CB856600
Pays : International
Organisme : the National Natural Science Foundation of China
ID : 21632001, 81821004
Pays : International
Organisme : the National Natural Science Foundation of China
ID : 21871011
Pays : International
Organisme : the Drug Innovation Major Project
ID : 2018ZX09711-001
Pays : International
Organisme : the Open Research Fund of Shanghai Key Laboratory of Green Chemistry and Chemical Processes
ID : the Open Research Fund
Pays : International
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.