Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study.


Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213

Informations de publication

Date de publication:
02 01 2020
Historique:
received: 07 02 2019
accepted: 24 05 2019
pubmed: 28 5 2019
medline: 7 1 2021
entrez: 28 5 2019
Statut: ppublish

Résumé

In this prospective cohort study of Bangladeshi children, greater fecal immunoglobulin A, but not plasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12 months of age was associated with delayed time to subsequent cryptosporidiosis. This finding suggests a protective role for mucosal antibody-mediated immunity in naturally exposed children.

Identifiants

pubmed: 31131855
pii: 5498859
doi: 10.1093/cid/ciz430
pmc: PMC6938969
doi:

Substances chimiques

Antibodies, Protozoan 0
Immunoglobulin A 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

323-326

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI043596
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007046
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055432
Pays : United States

Informations de copyright

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

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Auteurs

Kevin L Steiner (KL)

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville.

Mamun Kabir (M)

icddr,b, Dhaka, Bangladesh.

Jeffrey W Priest (JW)

Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.

Biplob Hossain (B)

icddr,b, Dhaka, Bangladesh.

Carol A Gilchrist (CA)

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville.

Heather Cook (H)

Department of Statistics, School of Medicine, University of Virginia, Charlottesville.

Jennie Z Ma (JZ)

Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of Virginia, Charlottesville.

Poonum S Korpe (PS)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Tahmeed Ahmed (T)

icddr,b, Dhaka, Bangladesh.

A S G Faruque (ASG)

icddr,b, Dhaka, Bangladesh.

Rashidul Haque (R)

icddr,b, Dhaka, Bangladesh.

William A Petri (WA)

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville.

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