NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond.
Mitochondria
NF-κB
OXPHOS
ROS
Revers Warburg effect
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
09
04
2019
revised:
21
05
2019
accepted:
22
05
2019
pubmed:
28
5
2019
medline:
23
12
2020
entrez:
28
5
2019
Statut:
ppublish
Résumé
NF-κB plays a pivotal role in oncogenesis. This transcription factor is best known for promoting cancer cell survival and tumour-driving inflammation. However, several lines of evidence support a crucial role for NF-κB in governing energy homeostasis and mediating cancer metabolic reprogramming. Mitochondria are central players in many metabolic processes altered in cancer. Beyond their bioenergetic activity, several facets of mitochondria biology, including mitochondrial dynamics and oxidative stress, promote and sustain malignant transformation. Recent reports revealed an intimate connection between NF-κB pathway and the oncogenic mitochondrial functions. NF-κB can impact mitochondrial respiration and mitochondrial dynamics, and, reciprocally, mitochondria can sense stress signals and convert them into cell biological responses leading to NF-κB activation. In this review we discuss their emerging reciprocal regulation and the significance of this interplay for anticancer therapy.
Identifiants
pubmed: 31132468
pii: S1084-9521(18)30183-6
doi: 10.1016/j.semcdb.2019.05.021
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
NF-kappa B
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118-128Subventions
Organisme : Medical Research Council
ID : MR/L005069/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.