The viral protein corona directs viral pathogenesis and amyloid aggregation.
Alzheimer Disease
/ immunology
Amyloid beta-Peptides
/ metabolism
Animals
Bronchoalveolar Lavage Fluid
/ virology
Cell Line, Tumor
Chlorocebus aethiops
Disease Models, Animal
Female
Healthy Volunteers
Herpes Simplex
/ blood
Herpesvirus 1, Human
/ immunology
Host-Pathogen Interactions
/ immunology
Humans
Male
Mice
Mice, Transgenic
Peptide Fragments
/ metabolism
Protein Aggregates
/ immunology
Protein Corona
/ immunology
Respiratory Syncytial Virus Infections
/ immunology
Respiratory Syncytial Virus, Human
/ immunology
Vero Cells
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 05 2019
27 05 2019
Historique:
received:
16
01
2019
accepted:
26
04
2019
entrez:
29
5
2019
pubmed:
28
5
2019
medline:
14
6
2019
Statut:
epublish
Résumé
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating differentially affects viral infectivity and immune cell activation. In addition, we demonstrate that viruses bind amyloidogenic peptides in their corona and catalyze amyloid formation via surface-assisted heterogeneous nucleation. Importantly, we show that HSV-1 catalyzes the aggregation of the amyloid β-peptide (Aβ
Identifiants
pubmed: 31133680
doi: 10.1038/s41467-019-10192-2
pii: 10.1038/s41467-019-10192-2
pmc: PMC6536551
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
Protein Aggregates
0
Protein Corona
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2331Subventions
Organisme : Medical Research Council
ID : MR/N024850/1
Pays : United Kingdom
Références
Alzheimers Dement (Amst). 2017 Feb 09;7:69-87
pubmed: 28275702
Biochim Biophys Acta. 2009 Jul;1792(7):714-21
pubmed: 18760350
Sci Transl Med. 2016 May 25;8(340):340ra72
pubmed: 27225182
Nat Nanotechnol. 2011 Jan;6(1):39-44
pubmed: 21170037
Sci Adv. 2019 Jan 23;5(1):eaau3333
pubmed: 30746447
ACS Nano. 2014 Apr 22;8(4):3357-66
pubmed: 24617595
Semin Thromb Hemost. 2016 Jun;42(4):408-21
pubmed: 27056151
Viral Immunol. 2000;13(1):125-35
pubmed: 10733174
J Virol. 2015 Jan 15;89(2):917-30
pubmed: 25355874
Nat Nanotechnol. 2013 Oct;8(10):772-81
pubmed: 24056901
Neuron. 2018 Jul 11;99(1):64-82.e7
pubmed: 29937276
Sci STKE. 2006 Mar 21;2006(327):pe14
pubmed: 16552091
J Virol. 1973 Nov;12(5):1173-80
pubmed: 4128827
ACS Chem Neurosci. 2010 Apr 21;1(4):279-87
pubmed: 22778827
J Proteome Res. 2017 Nov 3;16(11):3954-3960
pubmed: 28965415
Nanoscale. 2013 Apr 7;5(7):2570-88
pubmed: 23463168
Neurosci Lett. 2007 Dec 18;429(2-3):95-100
pubmed: 17980964
Nat Cell Biol. 2003 Jan;5(1):59-63
pubmed: 12483219
Nanotoxicology. 2016 Nov;10(9):1385-94
pubmed: 27465202
Nat Med. 2011 Aug 14;17(9):1132-5
pubmed: 21841784
Arch Toxicol. 2017 Mar;91(3):1031-1048
pubmed: 27438349
J Virol. 2007 Dec;81(24):13783-93
pubmed: 17913825
Small. 2016 Apr 6;12(13):1758-69
pubmed: 26853911
Immunol Rev. 2016 Nov;274(1):172-190
pubmed: 27782331
Cell. 2007 Dec 14;131(6):1059-71
pubmed: 18083097
Front Pharmacol. 2014 May 07;5:97
pubmed: 24847267
Vaccine. 2017 Jan 11;35(3):469-480
pubmed: 27908639
J Infect Dis. 1991 Apr;163(4):693-8
pubmed: 2010624
Nat Commun. 2015 Jan 22;6:5980
pubmed: 25609143
Angew Chem Int Ed Engl. 2016 Sep 5;55(37):11242-6
pubmed: 27513605
PLoS Pathog. 2019 Mar 14;15(3):e1007617
pubmed: 30870531
Nat Chem. 2018 Jun;10(6):673-683
pubmed: 29736006
J Neuroimmunol. 2017 Jul 15;308:43-49
pubmed: 28302316
Lancet Infect Dis. 2013 Nov;13(11):976-86
pubmed: 24156898
Int Rev Cell Mol Biol. 2017;329:187-226
pubmed: 28109328
J Neurosci. 2006 Oct 4;26(40):10129-40
pubmed: 17021169
Nat Nanotechnol. 2012 Dec;7(12):779-86
pubmed: 23212421
Cell. 2008 Feb 8;132(3):397-409
pubmed: 18267072
Neuron. 2018 Jul 11;99(1):56-63.e3
pubmed: 30001512
Front Immunol. 2012 Nov 27;3:354
pubmed: 23230437
PLoS Pathog. 2016 May 06;12(5):e1005622
pubmed: 27152417
J Biol Chem. 2015 Jul 31;290(31):18991-8
pubmed: 26055713
J Neuroimmune Pharmacol. 2011 Jun;6(2):188-201
pubmed: 21222046
Science. 2012 Nov 9;338(6108):795-8
pubmed: 23019612
Lancet. 2010 May 1;375(9725):1545-55
pubmed: 20399493
J Cell Sci. 2011 Mar 15;124(Pt 6):879-91
pubmed: 21325030
Cell Host Microbe. 2011 Apr 21;9(4):286-98
pubmed: 21501828
J Biol Chem. 2002 Sep 20;277(38):35019-24
pubmed: 12119288
Neurotherapeutics. 2018 Apr;15(2):417-429
pubmed: 29488144
Adv Mater. 2019 Nov;31(45):e1805740
pubmed: 30589115
J Virol Methods. 1991 Feb-Mar;31(2-3):161-70
pubmed: 1650782
Immunol Rev. 2011 Jan;239(1):149-66
pubmed: 21198670
Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E782-E791
pubmed: 29311311
PLoS Pathog. 2012 Feb;8(2):e1002519
pubmed: 22346752
Proc Natl Acad Sci U S A. 2007 May 22;104(21):8691-6
pubmed: 17485668
Front Aging Neurosci. 2018 Oct 19;10:324
pubmed: 30405395
J Virol. 2008 Mar;82(5):2040-55
pubmed: 17928346
Phys Chem Chem Phys. 2015 Mar 28;17(12):7606-18
pubmed: 25719972
J Am Chem Soc. 2010 Apr 28;132(16):5761-8
pubmed: 20356039
Biophys J. 1990 Dec;58(6):1501-16
pubmed: 2177356
Future Virol. 2011 Aug;6(8):963-973
pubmed: 21887154