No Association of Variants of the NPY-System With Obsessive-Compulsive Disorder in Children and Adolescents.
NPY
anxiety
children
neuropeptide
obsessive-compulsive
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
07
2018
accepted:
17
04
2019
entrez:
29
5
2019
pubmed:
28
5
2019
medline:
28
5
2019
Statut:
epublish
Résumé
Obsessive-compulsive disorder (OCD) causes severe distress and is therefore counted by the World Health Organisation (WHO) as one of the 10 most impairing illnesses. There is evidence for a strong genetic underpinning especially in early onset OCD (eoOCD). Though several genes involved in neurotransmission have been reported as candidates, there is still a need to identify new pathways. In this study, we focussed on genetic variants of the Neuropeptide Y (NPY) system. NPY is one of the most abundant neuropeptides in the human brain with emerging evidence of capacity to modulate stress response, which is of high relevance in OCD. We focussed on tag-SNPs of
Identifiants
pubmed: 31133798
doi: 10.3389/fnmol.2019.00112
pmc: PMC6511743
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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