Age-Dependent Changes in Transcription Factor FOXO Targeting in Female
ChIP-Seq
MAPK
forkhead transcription factor FOXO
hippo
histone
insulin
longevity control
transcriptional regulation
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
12
2018
accepted:
21
03
2019
entrez:
29
5
2019
pubmed:
28
5
2019
medline:
28
5
2019
Statut:
epublish
Résumé
FOXO transcription factors have long been associated with longevity control and tissue homeostasis. Although the transcriptional regulation of FOXO have been previously characterized (especially in long-lived insulin mutants and under stress conditions), how normal aging impacts the transcriptional activity of FOXO is poorly understood. Here, we conducted a chromatin immunoprecipitation sequencing (ChIP-Seq) analysis in both young (2-week-old) and aged (5-week-old) wild-type female fruit flies,
Identifiants
pubmed: 31134124
doi: 10.3389/fgene.2019.00312
pmc: PMC6514159
doi:
Types de publication
Journal Article
Langues
eng
Pagination
312Subventions
Organisme : NIA NIH HHS
ID : R00 AG048016
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG024360
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058741
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG024360
Pays : United States
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