Tools and systems for evolutionary engineering of biomolecules and microorganisms.

Continuous evolution Evolutionary engineering High-throughput screening Mutagenesis Selection

Journal

Journal of industrial microbiology & biotechnology
ISSN: 1476-5535
Titre abrégé: J Ind Microbiol Biotechnol
Pays: Germany
ID NLM: 9705544

Informations de publication

Date de publication:
Oct 2019
Historique:
received: 28 02 2019
accepted: 20 05 2019
pubmed: 28 5 2019
medline: 23 1 2020
entrez: 29 5 2019
Statut: ppublish

Résumé

Evolutionary approaches have been providing solutions to various bioengineering challenges in an efficient manner. In addition to traditional adaptive laboratory evolution and directed evolution, recent advances in synthetic biology and fluidic systems have opened a new era of evolutionary engineering. Synthetic genetic circuits have been created to control mutagenesis and enable screening of various phenotypes, particularly metabolite production. Fluidic systems can be used for high-throughput screening and multiplexed continuous cultivation of microorganisms. Moreover, continuous directed evolution has been achieved by combining all the steps of evolutionary engineering. Overall, modern tools and systems for evolutionary engineering can be used to establish the artificial equivalent to natural evolution for various research applications.

Identifiants

pubmed: 31134415
doi: 10.1007/s10295-019-02191-5
pii: 10.1007/s10295-019-02191-5
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1313-1326

Subventions

Organisme : National Research Foundation of Korea
ID : NRF-2016K1A1A2912829
Organisme : Korea Institute of Energy Technology Evaluation and Planning
ID : 20174030201600

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Auteurs

Sungho Jang (S)

Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Korea.

Minsun Kim (M)

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Korea.

Jaeseong Hwang (J)

School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Korea.

Gyoo Yeol Jung (GY)

Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Korea. gyjung@postech.ac.kr.
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, Korea. gyjung@postech.ac.kr.

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