The role of gut micorbiome in obesity and diabetes.
Diabetes
Microbiome
Obesity
Journal
World journal of pediatrics : WJP
ISSN: 1867-0687
Titre abrégé: World J Pediatr
Pays: Switzerland
ID NLM: 101278599
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
18
12
2018
accepted:
07
05
2019
pubmed:
28
5
2019
medline:
7
3
2020
entrez:
29
5
2019
Statut:
ppublish
Résumé
Obesity and diabetes became a grooving problem in both adults and children. Many hypotheses concerned agents involved in the excessive weight gain process and it's consequences. Not only genetic or environmental factors, but also intestinal microbiome seems to play a role in the pathophysiology of this phenomenon. A systematic review was conducted using Pubmed as the medical database source. Studies concerning connection between microbiome and metabolic disorders such as obesity and diabetes from last 10 years were analyzed. Intestinal bacteria may be involved both in the development of obesity, and its further complications. The pro-inflammatory and immunomodulating effect of dysbiosis are possible triggers of insulin resistance and diabetes. Early interventions aimed at the microbiome, as well as attempts to modify the microbiome at later stages may become new opportunities in the prevention and treatment of obesity and carbohydrate metabolism disorders. The gut microbiome has been shown to be an important part of the metabolic processes. The use of probiotic, prebiotics and symbiotics is promising, but requires further investigations to determine the specific metabolic effects of each bacteria strain and substance.
Sections du résumé
BACKGROUND
BACKGROUND
Obesity and diabetes became a grooving problem in both adults and children. Many hypotheses concerned agents involved in the excessive weight gain process and it's consequences. Not only genetic or environmental factors, but also intestinal microbiome seems to play a role in the pathophysiology of this phenomenon.
DATA SOURCES
METHODS
A systematic review was conducted using Pubmed as the medical database source. Studies concerning connection between microbiome and metabolic disorders such as obesity and diabetes from last 10 years were analyzed.
RESULTS
RESULTS
Intestinal bacteria may be involved both in the development of obesity, and its further complications. The pro-inflammatory and immunomodulating effect of dysbiosis are possible triggers of insulin resistance and diabetes. Early interventions aimed at the microbiome, as well as attempts to modify the microbiome at later stages may become new opportunities in the prevention and treatment of obesity and carbohydrate metabolism disorders.
CONCLUSIONS
CONCLUSIONS
The gut microbiome has been shown to be an important part of the metabolic processes. The use of probiotic, prebiotics and symbiotics is promising, but requires further investigations to determine the specific metabolic effects of each bacteria strain and substance.
Identifiants
pubmed: 31134588
doi: 10.1007/s12519-019-00267-x
pii: 10.1007/s12519-019-00267-x
doi:
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
332-340Références
Am J Clin Nutr. 2010 Nov;92(5):1023-30
pubmed: 20844065
Pediatr Res. 2012 Jul;72(1):77-85
pubmed: 22453296
Microb Pathog. 2012 Aug;53(2):100-8
pubmed: 22634320
Int J Obes (Lond). 2013 Jul;37(7):900-6
pubmed: 23670220
J Complement Integr Med. 2013 Aug 06;10:null
pubmed: 23921494
J Hepatol. 2014 Apr;60(4):824-31
pubmed: 24316517
PLoS One. 2014 Feb 26;9(2):e87896
pubmed: 24586295
J Food Sci. 2014 Apr;79(4):R442-51
pubmed: 24621052
BMJ Open. 2014 May 15;4(5):e005031
pubmed: 24833693
Nat Commun. 2014 May 20;5:3889
pubmed: 24846660
J Am Coll Nutr. 2014;33(6):417-25
pubmed: 25079040
Horm Mol Biol Clin Investig. 2014 Jan;17(1):53-61
pubmed: 25372730
PLoS One. 2014 Nov 19;9(11):e113026
pubmed: 25409177
BMC Med. 2014 Nov 25;12:215
pubmed: 25420418
FASEB J. 2015 Jun;29(6):2397-411
pubmed: 25713030
Crit Rev Food Sci Nutr. 2017 May 24;57(8):1569-1583
pubmed: 25875150
Obesity (Silver Spring). 2015 Jun;23(6):1252-8
pubmed: 25960251
Expert Rev Gastroenterol Hepatol. 2015;9(8):1087-99
pubmed: 26082274
Gut. 2016 Mar;65(3):426-36
pubmed: 26100928
Curr Opin Clin Nutr Metab Care. 2015 Sep;18(5):515-20
pubmed: 26154278
Benef Microbes. 2015;6(6):775-82
pubmed: 26259892
Pol Arch Med Wewn. 2015;125(11):803-13
pubmed: 26431318
Nutr Clin Pract. 2015 Dec;30(6):787-97
pubmed: 26452391
Trends Immunol. 2015 Nov;36(11):684-696
pubmed: 26497259
JAMA Pediatr. 2016 Jan;170(1):20-8
pubmed: 26552054
JAMA Pediatr. 2016 Mar;170(3):212-9
pubmed: 26752321
Br J Nutr. 2016 Apr 14;115(7):1167-77
pubmed: 26899960
Medicina (Kaunas). 2016;52(1):28-34
pubmed: 26987497
Eur J Nutr. 2017 Jun;56(4):1535-1550
pubmed: 26988693
J Allergy Clin Immunol. 2016 Sep;138(3):881-889.e2
pubmed: 27045582
Int J Food Sci Nutr. 2015 Aug;67(5):571-80
pubmed: 27149163
Diabetes Metab. 2016 Sep;42(4):234-41
pubmed: 27209439
Physiology (Bethesda). 2016 Jul;31(4):283-93
pubmed: 27252163
Medicine (Baltimore). 2016 Jun;95(26):e4088
pubmed: 27368052
Diabetes Res Clin Pract. 2016 Aug;118:172-82
pubmed: 27388674
Cell Metab. 2016 Jul 12;24(1):63-74
pubmed: 27411009
JAMA Pediatr. 2016 Nov 7;170(11):e162385
pubmed: 27599167
World J Gastroenterol. 2016 Oct 28;22(40):8905-8909
pubmed: 27833381
Nutr Rev. 2016 Dec;74(12):774-784
pubmed: 27864537
Int J Obes (Lond). 2017 Apr;41(4):497-501
pubmed: 27899809
J Med Life. 2016 Oct-Dec;9(4):386-391
pubmed: 27928443
Diabetes Obes Metab. 2017 Apr;19(4):579-589
pubmed: 28009106
J Clin Invest. 2017 Jan 3;127(1):65-73
pubmed: 28045405
Gut Microbes. 2017 Mar 4;8(2):143-171
pubmed: 28068209
Nutrients. 2017 Mar 15;9(3):null
pubmed: 28294985
Br J Nutr. 2017 Mar;117(6):804-813
pubmed: 28367765
Aust Fam Physician. 2017;46(4):206-211
pubmed: 28376573
Pediatr Obes. 2017 Aug;12 Suppl 1:3-17
pubmed: 28447406
Benef Microbes. 2017 May 30;8(3):353-365
pubmed: 28504574
Nat Rev Immunol. 2017 Aug;17(8):508-517
pubmed: 28604736
Benef Microbes. 2017 Aug 24;8(4):535-543
pubmed: 28618860
J Endocrinol. 2017 Oct;235(1):R1-R12
pubmed: 28751453
Int J Obes (Lond). 2018 Jan;42(1):8-14
pubmed: 28775373
Microbiome. 2017 Sep 4;5(1):113
pubmed: 28870230
Front Microbiol. 2017 Nov 22;8:2306
pubmed: 29213261
J Am Coll Cardiol. 2018 Jan 2;71(1):69-84
pubmed: 29301630
JAMA Pediatr. 2018 Apr 1;172(4):368-377
pubmed: 29459942
Am J Clin Nutr. 2018 Mar 1;107(3):313-322
pubmed: 29566190
J Med Food. 2018 May;21(5):454-461
pubmed: 29688793
Pediatr Obes. 2018 Oct;13(10):579-589
pubmed: 29797797
Child Obes. 2018 Jul;14(5):327-337
pubmed: 29912590
Front Genet. 2018 Jun 19;9:203
pubmed: 29971089
Nutrients. 2018 Jul 12;10(7):null
pubmed: 30002323
Diabetologia. 2018 Dec;61(12):2668-2670
pubmed: 30238182
Nat Commun. 2018 Oct 9;9(1):4169
pubmed: 30301893
MBio. 2018 Oct 23;9(5):
pubmed: 30352933
Prev Med. 2019 Jan;118:210-215
pubmed: 30412742