Allodepleted T-cell immunotherapy after haploidentical haematopoietic stem cell transplantation without severe acute graft-versus-host disease (GVHD) in the absence of GVHD prophylaxis.
cell therapy and immunotherapy
graft-versus-host-disease
haematopoietic stem cell
stem cell transplantation
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
29
01
2019
accepted:
12
03
2019
pubmed:
29
5
2019
medline:
17
7
2020
entrez:
29
5
2019
Statut:
ppublish
Résumé
Graft-versus-host disease (GVHD) is a major cause of transplant-related mortality (TRM) after allogeneic haematopoietic stem cell transplantation (HSCT) and presents a challenge in haploidentical HSCT. GVHD may be prevented by ex vivo graft T-cell depletion or in vivo depletion of proliferating lymphocytes. However, both approaches pose significant risks, particularly infections and relapse, compromising survival. A photodepletion strategy to eliminate alloreactive T cells from mismatched donor lymphocyte infusions (enabling administration without immunosuppression), was used to develop ATIR101, an adjunctive therapy for use after haploidentical HSCT. In this phase I dose-finding study, 19 adults (median age: 54 years) with high-risk haematological malignancies were treated with T-cell-depleted human leucocyte antigen-haploidentical myeloablative HSCT followed by ATIR101 at doses of 1 × 10
Identifiants
pubmed: 31135970
doi: 10.1111/bjh.15970
pmc: PMC6771482
doi:
Banques de données
ClinicalTrials.gov
['NCT00993486']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
754-766Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.
Références
Semin Oncol. 2012 Dec;39(6):674-82
pubmed: 23206844
Blood. 2004 Feb 1;103(3):767-76
pubmed: 12958064
Biol Blood Marrow Transplant. 2018 May;24(5):895-908
pubmed: 29339270
Bone Marrow Transplant. 2013 Mar;48(3):346-50
pubmed: 22863723
Semin Hematol. 2016 Oct;53(4):252-256
pubmed: 27788763
Bone Marrow Transplant. 2003 Jan;31(1):39-44
pubmed: 12621505
Biol Blood Marrow Transplant. 2005 Dec;11(12):945-56
pubmed: 16338616
Immunol Today. 1998 Feb;19(2):69-74
pubmed: 9509761
Front Immunol. 2016 Nov 17;7:507
pubmed: 27909435
Blood. 2006 Sep 15;108(6):1797-808
pubmed: 16741253
Blood. 2014 Jul 24;124(4):638-44
pubmed: 24923299
Transplantation. 1999 Jan 15;67(1):124-30
pubmed: 9921808
N Engl J Med. 2017 Dec 28;377(26):2565-2579
pubmed: 29281578
J Clin Invest. 2015 Jul 1;125(7):2677-89
pubmed: 26053664
Haematologica. 2015 May;100(5):683-9
pubmed: 25769546
N Engl J Med. 1998 Oct 22;339(17):1186-93
pubmed: 9780338
Lancet. 2002 Jul 13;360(9327):130-7
pubmed: 12126823
J Exp Med. 2008 Mar 17;205(3):711-23
pubmed: 18332179
Biol Blood Marrow Transplant. 2010 Nov;16(11):1541-8
pubmed: 20800103
Blood. 2010 Dec 2;116(23):4859-69
pubmed: 20798236
Blood. 2011 Jul 14;118(2):282-8
pubmed: 21527516
Blood. 2015 Jun 25;125(26):4103-13
pubmed: 25977584
Bone Marrow Transplant. 2018 Sep;53(9):1139-1148
pubmed: 29540849
Cancer Treat Rev. 2010 Nov;36(7):528-38
pubmed: 20381970
Bone Marrow Transplant. 2010 May;45(5):807-10
pubmed: 20190834
Blood Adv. 2018 Feb 13;2(3):299-307
pubmed: 29440002
Blood. 1998 Jul 1;92(1):101-7
pubmed: 9639505
Blood. 2017 Aug 3;130(5):677-685
pubmed: 28588018
Blood. 2011 Oct 27;118(17):4732-9
pubmed: 21868572
Sci Transl Med. 2013 Apr 3;5(179):179ra43
pubmed: 23552371
Blood. 2007 Sep 1;110(5):1689-97
pubmed: 17478639
Blood. 2002 Jul 15;100(2):375-82
pubmed: 12091325
Leukemia. 2015 Sep;29(9):1891-900
pubmed: 25882700
Transplantation. 1974 Oct;18(4):295-304
pubmed: 4153799
Science. 1999 Oct 29;286(5441):958-61
pubmed: 10542151
J Clin Oncol. 2017 Sep 10;35(26):3002-3009
pubmed: 28644773
N Engl J Med. 2011 Nov 3;365(18):1673-83
pubmed: 22047558
Bone Marrow Transplant. 2016 Jul;51(7):915-8
pubmed: 27088377
J Immunol. 2010 Jun 15;184(12):6739-45
pubmed: 20483749
Blood. 2012 Mar 1;119(9):1972-80
pubmed: 22210876
Blood. 2015 Aug 20;126(8):1033-40
pubmed: 26130705
Blood. 2013 Jan 31;121(5):752-8
pubmed: 23223509
Biol Blood Marrow Transplant. 2008 Jun;14(6):641-50
pubmed: 18489989
N Engl J Med. 2011 Dec 1;365(22):2055-66
pubmed: 22129252
Blood. 2002 May 1;99(9):3083-8
pubmed: 11964269
Blood Cells Mol Dis. 2008 Jan-Feb;40(1):76-83
pubmed: 17977031
J Clin Invest. 2003 Jul;112(1):101-8
pubmed: 12840064
Biol Blood Marrow Transplant. 2011 May;17(5):591-7
pubmed: 20732435
Lancet Oncol. 2009 May;10(5):489-500
pubmed: 19345145
Bone Marrow Transplant. 2015 Aug;50(8):1037-56
pubmed: 25798672
Blood. 2008 Apr 15;111(8):4392-402
pubmed: 17878399