Low Responsiveness of Basophils via FcεRI Reflects Disease Activity in Chronic Spontaneous Urticaria.
Basophil activation test
CD203c
Chronic spontaneous urticaria
Journal
The journal of allergy and clinical immunology. In practice
ISSN: 2213-2201
Titre abrégé: J Allergy Clin Immunol Pract
Pays: United States
ID NLM: 101597220
Informations de publication
Date de publication:
Historique:
received:
04
02
2019
revised:
10
05
2019
accepted:
17
05
2019
pubmed:
29
5
2019
medline:
9
10
2020
entrez:
29
5
2019
Statut:
ppublish
Résumé
The insufficient effect of H1-antihistamine in some patients with chronic spontaneous urticaria (CSU) suggests that factors other than histamine are involved in the pathophysiology of CSU. Moreover, a central role for basophils in the pathophysiology of CSU has been hypothesized. However, few studies have focused on the relationship between basophil reactivity via FcεRI and clinical features in patients with CSU. To assess basophil reactivity via FcεRI against anti-IgE and FcεRI stimulation in patients with CSU, and its association with disease activity in CSU. FcεRI expression and IgE binding on basophils from patients with CSU were also investigated. We analyzed 38 patients with CSU, 8 patients with atopic dermatitis (AD), and 11 healthy controls (HCs). The surface CD203c expression with or without anti-IgE or FcεRI stimulation, and IgE and FcεRI (CRA1, CRA2) expression on blood basophils were evaluated. Patients with CSU were also evaluated and classified by disease activity and the above parameters were compared. The proportion of CD203c Low reactivity of basophils via FcεRI is characteristic of patients with CSU. This attenuated reactivity is associated with severe clinical activity in patients with CSU (250 of 250).
Sections du résumé
BACKGROUND
The insufficient effect of H1-antihistamine in some patients with chronic spontaneous urticaria (CSU) suggests that factors other than histamine are involved in the pathophysiology of CSU. Moreover, a central role for basophils in the pathophysiology of CSU has been hypothesized. However, few studies have focused on the relationship between basophil reactivity via FcεRI and clinical features in patients with CSU.
OBJECTIVE
To assess basophil reactivity via FcεRI against anti-IgE and FcεRI stimulation in patients with CSU, and its association with disease activity in CSU. FcεRI expression and IgE binding on basophils from patients with CSU were also investigated.
METHODS
We analyzed 38 patients with CSU, 8 patients with atopic dermatitis (AD), and 11 healthy controls (HCs). The surface CD203c expression with or without anti-IgE or FcεRI stimulation, and IgE and FcεRI (CRA1, CRA2) expression on blood basophils were evaluated. Patients with CSU were also evaluated and classified by disease activity and the above parameters were compared.
RESULTS
The proportion of CD203c
CONCLUSIONS
Low reactivity of basophils via FcεRI is characteristic of patients with CSU. This attenuated reactivity is associated with severe clinical activity in patients with CSU (250 of 250).
Identifiants
pubmed: 31136822
pii: S2213-2198(19)30477-5
doi: 10.1016/j.jaip.2019.05.020
pii:
doi:
Substances chimiques
Receptors, IgE
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2835-2844.e7Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.