Simultaneous determination of parabens, bisphenols and alkylphenols in human placenta by ultra-high performance liquid chromatography-tandem mass spectrometry.
Alkylphenol
Bisphenol
Endocrine disruptor
Paraben
Placenta
UHPLC-MS/MS
Journal
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
ISSN: 1873-376X
Titre abrégé: J Chromatogr B Analyt Technol Biomed Life Sci
Pays: Netherlands
ID NLM: 101139554
Informations de publication
Date de publication:
15 Jul 2019
15 Jul 2019
Historique:
received:
22
06
2018
revised:
07
05
2019
accepted:
12
05
2019
pubmed:
29
5
2019
medline:
21
8
2019
entrez:
29
5
2019
Statut:
ppublish
Résumé
This study presents de development and validation of an ultra- high performance liquid chromatography - tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of four parabens (methyl-, ethyl-, propyl-, and butyl-paraben (MeP, EtP, PrP, BuP), four bisphenols (BP) (BPA, BPB, BPF, and BPS) and two alkylphenols (nonyl phenol (NP) and tert-octylphenol (OP) in human placenta samples. After a short sample preparation time the extracts are analysed by UHPLC-MS/MS using negative electrospray ionization. Labeled internal standards and matrix-matched calibration are used for quantification of the compounds. The method was validated according FDA guideline for bio analytical methods using spiked samples at three concentration levels (0.5-5 and 25 ng g
Identifiants
pubmed: 31136871
pii: S1570-0232(18)30962-0
doi: 10.1016/j.jchromb.2019.05.012
pii:
doi:
Substances chimiques
Parabens
0
Phenols
0
Types de publication
Journal Article
Langues
eng
Pagination
96-102Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.