Accumulation of Innate Amyloid Beta Peptide in Glioblastoma Tumors.
Aβ peptide
amyloid
glioma
platelets
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 May 2019
20 May 2019
Historique:
received:
08
04
2019
revised:
23
04
2019
accepted:
15
05
2019
entrez:
30
5
2019
pubmed:
30
5
2019
medline:
12
11
2019
Statut:
epublish
Résumé
Immunostaining with specific antibodies has shown that innate amyloid beta (Aβ) is accumulated naturally in glioma tumors and nearby blood vessels in a mouse model of glioma. In immunofluorescence images, Aβ peptide coincides with glioma cells, and enzyme-linked immunosorbent assay (ELISA) have shown that Aβ peptide is enriched in the membrane protein fraction of tumor cells. ELISAs have also confirmed that the Aβ(1-40) peptide is enriched in glioma tumor areas relative to healthy brain areas. Thioflavin staining revealed that at least some amyloid is present in glioma tumors in aggregated forms. We may suggest that the presence of aggregated amyloid in glioma tumors together with the presence of Aβ immunofluorescence coinciding with glioma cells and the nearby vasculature imply that the source of Aβ peptides in glioma can be systemic Aβ from blood vessels, but this question remains unresolved and needs additional studies.
Identifiants
pubmed: 31137462
pii: ijms20102482
doi: 10.3390/ijms20102482
pmc: PMC6567111
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
amyloid beta-protein (1-40)
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : SC1 GM122691
Pays : United States
Organisme : National Institutes of Health
ID : SC1GM122691 to L.K., SC2GM111149 to M.I
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