A Multidisciplinary Team Guided Approach to the Management of cT3 Laryngeal Cancer: A Retrospective Analysis of 104 Cases.
head and neck cancer
laryngeal cancer
laryngeal neoplasm
laryngo-esophageal disfunction
multidisciplinary team
prognosis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 May 2019
24 May 2019
Historique:
received:
14
04
2019
revised:
21
05
2019
accepted:
22
05
2019
entrez:
30
5
2019
pubmed:
30
5
2019
medline:
30
5
2019
Statut:
epublish
Résumé
The optimal treatment for T3 laryngeal carcinoma (LC) is still a matter of debate. Different therapeutic options are available: Transoral laser microsurgery (TLM), open partial horizontal laryngectomies (OPHLs), total laryngectomy (TL), and organ preservation protocols (radiation therapy (RT) or chemo-radiation (CRT)). This study aimed to retrospectively evaluate oncologic outcomes of 104 T3 LCs treated by surgery or non-surgical approaches from January 2011 to December 2016 at a single academic tertiary referral center. Each case was evaluated by a multidisciplinary team (MDT) devoted to the management of head and neck cancers. We divided the cohort into two subgroups: Group A, surgical treatment (TLM, OPHLs, TL) and Group B, non-surgical treatment (RT, CRT). For the entire cohort, two- and five-year overall survival (OS) rates were 83% and 56%, respectively. The two- and five-year disease-free survival (DFS) rates were 75% and 65%, and disease-specific survival rates were 93% and 70%, respectively. The N category was a significant independent prognosticator for OS (
Identifiants
pubmed: 31137671
pii: cancers11050717
doi: 10.3390/cancers11050717
pmc: PMC6562846
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Head Neck. 2019 Jun;41(6):1816-1823
pubmed: 30636186
Laryngoscope. 2012 May;122(5):1043-50
pubmed: 22374653
Indian J Cancer. 2011 Jan-Mar;48(1):99-104
pubmed: 21248437
Postgrad Med J. 2008 Nov;84(997):609-12
pubmed: 19103820
N Engl J Med. 2004 Mar 4;350(10):1049-53; author reply 1049-53
pubmed: 14999119
Eur Arch Otorhinolaryngol. 2007 May;264(5):499-504
pubmed: 17377801
N Engl J Med. 2003 Nov 27;349(22):2091-8
pubmed: 14645636
Eur Arch Otorhinolaryngol. 2009 Jul;266(7):993-8
pubmed: 19130072
Otolaryngol Head Neck Surg. 2016 Aug;155(2):265-73
pubmed: 27026736
Int J Radiat Oncol Biol Phys. 2009 Apr 1;73(5):1293-303
pubmed: 19306746
J Clin Oncol. 2018 Apr 10;36(11):1143-1169
pubmed: 29172863
Otolaryngol Head Neck Surg. 2004 Jan;130(1):84-8
pubmed: 14726915
Eur Arch Otorhinolaryngol. 2014 Sep;271(9):2489-96
pubmed: 24691854
Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3463-8
pubmed: 25359194
Curr Opin Otolaryngol Head Neck Surg. 2014 Apr;22(2):131-9
pubmed: 24614061
Head Neck. 2016 Dec;38(12):1739-1751
pubmed: 27466789
Laryngoscope. 2006 Sep;116(9 Pt 2 Suppl 111):1-13
pubmed: 16946667
Eur Arch Otorhinolaryngol. 2014 Sep;271(9):2469-79
pubmed: 24609733
Front Oncol. 2018 May 28;8:186
pubmed: 29892574
Acta Otorhinolaryngol Ital. 2016 Dec;36(6):450-458
pubmed: 28177327
Head Neck. 2018 Sep;40(9):1897-1908
pubmed: 29756363
J Clin Oncol. 2006 Aug 1;24(22):3693-704
pubmed: 16832122
Arch Otolaryngol Head Neck Surg. 2007 Oct;133(10):1037-43
pubmed: 17938329
J Natl Compr Canc Netw. 2018 May;16(5):479-490
pubmed: 29752322
Acta Otolaryngol. 2019 Feb;139(2):167-171
pubmed: 30794035
Ann Otol Rhinol Laryngol. 2015 Nov;124(11):845-51
pubmed: 25991835
Eur Arch Otorhinolaryngol. 2000;257(4):227-31
pubmed: 10867840
Acta Otorhinolaryngol Ital. 2010 Aug;30(4):169
pubmed: 21253281
Laryngoscope. 2014 Nov;124(11):2561-7
pubmed: 24964904
Cancers (Basel). 2019 Jan 10;11(1):
pubmed: 30634566
Otolaryngol Head Neck Surg. 2009 Mar;140(3):386-90
pubmed: 19248948
Head Neck. 2016 Apr;38 Suppl 1:E649-57
pubmed: 25866908
JAMA Otolaryngol Head Neck Surg. 2014 Sep;140(9):855-60
pubmed: 25144163
Eur Arch Otorhinolaryngol. 2017 Oct;274(10):3679-3686
pubmed: 28631160
Arch Otolaryngol Head Neck Surg. 2007 Dec;133(12):1270-6
pubmed: 18086971
J Laryngol Otol. 2016 May;130(5):478-81
pubmed: 26975210
Front Oncol. 2018 May 22;8:175
pubmed: 29872643
Head Neck. 2011 Jan;33(1):31-6
pubmed: 20848430
Eur J Surg Oncol. 2017 Jan;43(1):20-31
pubmed: 27320417
Braz J Otorhinolaryngol. 2020 Mar - Apr;86(2):228-236
pubmed: 30683565
Acta Otorrinolaringol Esp. 2013 Mar-Apr;64(2):140-9
pubmed: 22503567
Front Oncol. 2017 Oct 16;7:245
pubmed: 29085805
Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2275-81
pubmed: 23568037
J Voice. 1998 Mar;12(1):117-22
pubmed: 9619988
Head Neck. 2008 Mar;30(3):372-9
pubmed: 17972314
Curr Opin Otolaryngol Head Neck Surg. 2016 Apr;24(2):135-9
pubmed: 26963672
Curr Otorhinolaryngol Rep. 2017;5(1):56-68
pubmed: 28367361
J Otolaryngol Head Neck Surg. 2012 Apr;41 Suppl 1:S56-64
pubmed: 22569051
Head Neck. 2011 Sep;33(9):1252-9
pubmed: 21837693
Acta Otorhinolaryngol Ital. 2012 Aug;32(4):229-37
pubmed: 23093812
Acta Otorhinolaryngol Ital. 2011 Apr;31(2):70-5
pubmed: 22065027
Ann Otol Rhinol Laryngol. 2015 Apr;124(4):294-8
pubmed: 25358609
Head Neck. 2016 Jul;38(7):1107-12
pubmed: 26970262
Cancers (Basel). 2019 Mar 01;11(3):
pubmed: 30832209