Preparation, Characterization, and Release Kinetics of Chitosan-Coated Nanoliposomes Encapsulating Curcumin in Simulated Environments.
chitosan
curcumin
gastrointestinal environment
nanoliposomes
release kinetics
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 May 2019
27 May 2019
Historique:
received:
06
05
2019
revised:
17
05
2019
accepted:
22
05
2019
entrez:
30
5
2019
pubmed:
30
5
2019
medline:
31
12
2019
Statut:
epublish
Résumé
Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic properties, yet, its sensitivity to light, oxygen, and heat, and its low solubility in water renders its preservation and bioavailability challenging. To increase its bioaccessibility, we fabricated nanoliposomes and chitosan-coated nanoliposomes encapsulating curcumin, and we evaluated the systems in terms of their physicochemical characteristics and release profiles in simulated gastrointestinal mediums. Chitosan-coating enhanced the stability of nanoliposomes and slowed the release of curcumin in the simulated gastrointestinal (GI) environment. This study demonstrates that nanoliposomes and chitosan-coated nanoliposomes are promising carriers for poorly soluble lipophilic compounds with low oral bioavailability, such as curcumin.
Identifiants
pubmed: 31137865
pii: molecules24102023
doi: 10.3390/molecules24102023
pmc: PMC6572090
pii:
doi:
Substances chimiques
Fatty Acids
0
Liposomes
0
Chitosan
9012-76-4
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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