The Effect of Upper Airway Surgery on Loop Gain in Obstructive Sleep Apnea.

Adult Cohort Studies Female Humans Laser Therapy / methods Male Middle Aged Otorhinolaryngologic Surgical Procedures / methods Polysomnography / methods Severity of Illness Index Sleep Apnea, Obstructive / physiopathology Treatment Outcome
hypoxemia loop gain lung obstructive sleep apnea upper airway surgery ventilatory control

Journal

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977

Informations de publication

Date de publication:
15 06 2019
Historique:
received: 17 07 2018
accepted: 18 02 2019
pubmed: 30 5 2019
medline: 21 10 2020
entrez: 30 5 2019
Statut: epublish

Résumé

Controversy exists as to whether elevated loop gain is a cause or consequence of obstructive sleep apnea (OSA). Upper airway surgery is commonly performed in Asian patients with OSA who have failed positive airway pressure therapy and who are thought to have anatomical predisposition to OSA. We hypothesized that high loop gain would decrease following surgical treatment of OSA due to reduced sleep apnea severity. Polysomnography was performed preoperatively and postoperatively to assess OSA severity in 30 Chinese participants who underwent upper airway surgery. Loop gain was calculated using a validated clinically-applicable method by fitting a feedback control model to airflow. Patients were followed up for a median (interquartile range) of 130 (62, 224) days after surgery. Apnea-hypopnea index (AHI) changed from 60.8 (33.7, 71.7) to 18.4 (9.9, 42.5) events/h ( High loop gain was reduced by surgical treatment of OSA in our cohort. These data suggest that elevated loop gain may be acquired in OSA and may provide mechanistic insight into improvement in OSA with upper airway surgery. Registry: ClinicalTrials.gov, Title: The Impact of Sleep Apnea Treatment on Physiology Traits in Chinese Patients With Obstructive Sleep Apnea, Identifier: NCT02696629, URL: https://clinicaltrials.gov/show/NCT02696629.

Identifiants

DOI: 10.5664/jcsm.7848 PMID: 31138381 PMC: PMC6557647
pubmed: 31138381
doi: 10.5664/jcsm.7848
pii: jc-18-00429
pmc: PMC6557647
doi:

Banques de données

ClinicalTrials.gov
['NCT02696629']

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

907-913

Subventions

Organisme : NHLBI NIH HHS
ID : T32 HL134632
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL085188
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL132105
Pays : United States
Organisme : NHLBI NIH HHS
ID : R21 HL121794
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119201
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL081823
Pays : United States

Informations de copyright

© 2019 American Academy of Sleep Medicine.

Références

Circulation. 1999 Mar 9;99(9):1183-9
pubmed: 10069786
JAMA. 2000 Dec 20;284(23):3015-21
pubmed: 11122588
J Appl Physiol (1985). 2004 Mar;96(3):1197-205; discussion 1196
pubmed: 14617525
Acta Physiol Scand. 1951 Feb 21;22(1):44-6
pubmed: 14933122
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32
pubmed: 15317668
Am Rev Respir Dis. 1992 Mar;145(3):527-32
pubmed: 1546831
ORL J Otorhinolaryngol Relat Spec. 2005;67(4):213-9
pubmed: 16103738
Chest. 2006 Sep;130(3):774-9
pubmed: 16963674
J Appl Physiol (1985). 2007 Dec;103(6):1929-41
pubmed: 17823298
Respir Physiol Neurobiol. 2008 Jul 31;162(2):144-51
pubmed: 18577470
Sleep. 2009 Jan;32(1):27-36
pubmed: 19189776
Am J Respir Crit Care Med. 2009 Nov 15;180(10):1002-9
pubmed: 19713446
Am J Respir Crit Care Med. 2010 Jan 15;181(2):189-93
pubmed: 19762565
J Physiol. 2009 Nov 15;587(Pt 22):5451-67
pubmed: 19805747
Sleep. 2009 Oct;32(10):1355-65
pubmed: 19848364
J Appl Physiol (1985). 2010 Feb;108(2):369-77
pubmed: 19940101
Eur Respir J. 2011 Apr;37(4):880-7
pubmed: 20947680
J Physiol. 2012 Mar 1;590(5):1199-211
pubmed: 22219335
Am J Respir Crit Care Med. 2013 Oct 15;188(8):996-1004
pubmed: 23721582
J Physiol. 2013 May 1;591(9):2233-4
pubmed: 23740880
J Physiol. 2014 Jul 15;592(14):2899-901
pubmed: 25027956
J Physiol. 2014 Jul 15;592(14):2903-5
pubmed: 25027957
Eur Respir J. 2015 Feb;45(2):408-18
pubmed: 25323235
Sleep Med Rev. 2015 Aug;22:3-14
pubmed: 25454671
Am J Respir Crit Care Med. 2016 Oct 1;194(7):878-885
pubmed: 26967681
Respirology. 2017 Jul;22(5):1015-1021
pubmed: 28303676
Sleep. 2017 Jul 1;40(7):
pubmed: 28531336

Auteurs

Yanru Li (Y)

Department of Otolaryngology Head and Neck Surgery and Clinical Center for OSAHS, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Capital Medical University, Beijing, China.
Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Jingying Ye (J)

Department of Otolaryngology Head and Neck Surgery and Clinical Center for OSAHS, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Capital Medical University, Beijing, China.
Department of Otolaryngology Head and Neck Surgery, Beijing Tsinghua Changgung Hospital, Beijing, China.

Demin Han (D)

Department of Otolaryngology Head and Neck Surgery and Clinical Center for OSAHS, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Capital Medical University, Beijing, China.

Di Zhao (D)

Department of Otolaryngology Head and Neck Surgery and Clinical Center for OSAHS, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Capital Medical University, Beijing, China.

Xin Cao (X)

Department of Otolaryngology Head and Neck Surgery and Clinical Center for OSAHS, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Key Laboratory of Otolaryngology Head and Neck Surgery (Ministry of Education of China), Capital Medical University, Beijing, China.
Department of Otolaryngology Head and Neck Surgery, Beijing Tsinghua Changgung Hospital, Beijing, China.

Jeremy Orr (J)

Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Rachel Jen (R)

Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Naomi Deacon-Diaz (N)

Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Scott A Sands (SA)

Division of Sleep Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Robert Owens (R)

Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

Atul Malhotra (A)

Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, San Diego, California.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Procédures de chirurgie opératoire › Techniques d'ablation › Thérapie laser › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie oto-rhino-laryngologique › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Monitorage physiologique › Polysomnographie › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Maladies du système nerveux › Syndromes d'apnées du sommeil › Syndrome d'apnées obstructives du sommeil › The Effect of Upper Airway Surgery on Loop...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › The Effect of Upper Airway Surgery on Loop...