A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans.
AXOS
dietary fiber
glucose homeostasis
lipidomics
metabolic syndrome
metabolomics
microbiome
overweight
Journal
mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636
Informations de publication
Date de publication:
28 May 2019
28 May 2019
Historique:
entrez:
30
5
2019
pubmed:
30
5
2019
medline:
30
5
2019
Statut:
epublish
Résumé
Long-term consumption of dietary fiber is generally considered beneficial for weight management and metabolic health, but the results of interventions vary greatly depending on the type of dietary fibers involved. This study provides a comprehensive evaluation of the effects of a specific dietary fiber consisting of a wheat-bran extract enriched in arabinoxylan-oligosaccharides (AXOS) in a human intervention trial. An integrated multi-omics analysis has been carried out to evaluate the effects of an intervention trial with an AXOS-enriched diet in overweight individuals with indices of metabolic syndrome. Microbiome analyses were performed by shotgun DNA sequencing in feces; in-depth metabolomics using nuclear magnetic resonance in fecal, urine, and plasma samples; and massive lipid profiling using mass spectrometry in fecal and serum/plasma samples. In addition to their bifidogenic effect, we observed that AXOS boost the proportion of
Identifiants
pubmed: 31138673
pii: 4/4/e00209-19
doi: 10.1128/mSystems.00209-19
pmc: PMC6538848
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02215343']
Types de publication
Journal Article
Langues
eng
Informations de copyright
Copyright © 2019 Benítez-Páez et al.
Références
J Clin Endocrinol Metab. 1999 Feb;84(2):541-5
pubmed: 10022413
J Lipid Res. 1999 Aug;40(8):1539-46
pubmed: 10428992
Tissue Cell. 2002 Feb;34(1):1-6
pubmed: 11989965
Clin Chem. 2002 Dec;48(12):2217-24
pubmed: 12446479
Proc Nutr Soc. 2003 Feb;62(1):3-9
pubmed: 12740050
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
J Am Soc Mass Spectrom. 2004 Oct;15(10):1499-508
pubmed: 15465363
Biochim Biophys Acta. 2004 Nov 8;1686(1-2):108-17
pubmed: 15522827
Prog Lipid Res. 2006 Jan;45(1):42-72
pubmed: 16445986
Biochim Biophys Acta. 2006 Jan;1761(1):121-8
pubmed: 16458590
Nutrition. 2006 May;22(5):504-11
pubmed: 16500082
Bioinformatics. 2006 Jul 1;22(13):1658-9
pubmed: 16731699
Horm Metab Res. 2006 Nov;38(11):761-6
pubmed: 17111305
FEMS Microbiol Ecol. 2007 Jul;61(1):121-31
pubmed: 17391327
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W182-5
pubmed: 17526522
J Lipid Res. 2008 May;49(5):1137-46
pubmed: 18281723
Genome Res. 2008 May;18(5):821-9
pubmed: 18349386
PLoS One. 2008;3(10):e3375
pubmed: 18846219
Bioinformatics. 2010 Jan 1;26(1):139-40
pubmed: 19910308
Br J Nutr. 2010 Mar;103(5):703-13
pubmed: 20003568
Eur J Clin Nutr. 2010 Aug;64(8):776-81
pubmed: 20485309
Nucleic Acids Res. 2010 Nov;38(20):e191
pubmed: 20805240
Anal Chem. 2010 Nov 1;82(21):8794-9
pubmed: 20945919
Crit Rev Food Sci Nutr. 2011 Feb;51(2):178-94
pubmed: 21328111
BMC Genomics. 2011 Sep 07;12:444
pubmed: 21899761
N Engl J Med. 2011 Nov 17;365(20):1876-85
pubmed: 22087679
Endocrinology. 2012 May;153(5):2223-33
pubmed: 22334723
Br J Nutr. 2012 Dec 28;108(12):2229-42
pubmed: 22370444
J Chromatogr B Analyt Technol Biomed Life Sci. 2012 May 15;897:98-104
pubmed: 22542399
J Nutr. 2012 Jul;142(7):1304-13
pubmed: 22649266
Nutr J. 2012 Jun 01;11:36
pubmed: 22657950
Nutrition. 2012 Nov-Dec;28(11-12):1115-21
pubmed: 22771050
Nucleic Acids Res. 2012 Nov 1;40(20):e155
pubmed: 22821567
J Proteome Res. 2013 Apr 5;12(4):1527-46
pubmed: 23342949
Eur J Epidemiol. 2013 Feb;28(2):119-30
pubmed: 23430035
J Lipid Res. 2013 Jun;54(6):1523-30
pubmed: 23549332
Bone. 2013 Nov;57(1):30-5
pubmed: 23871747
J Neurosci. 2013 Oct 23;33(43):17166-73
pubmed: 24155320
J Biosci Bioeng. 2014 Oct;118(4):476-81
pubmed: 24721123
Mol Metab. 2014 Jan 28;3(3):252-60
pubmed: 24749054
Lancet. 2015 Jun 20;385(9986):2510-20
pubmed: 25703114
Diabetes Metab Res Rev. 2015 Oct;31(7):734-44
pubmed: 25959529
J Nutr Sci. 2014 Oct 20;3:e49
pubmed: 26101617
Eur J Nutr. 2016 Jun;55(4):1661-70
pubmed: 26169871
Ann Nutr Metab. 2015;67(1):58-64
pubmed: 26279290
Cell Metab. 2015 Dec 1;22(6):971-82
pubmed: 26552345
Curr Obes Rep. 2015 Sep;4(3):303-10
pubmed: 26627487
Nucleic Acids Res. 2016 Jan 4;44(D1):D279-85
pubmed: 26673716
Cochrane Database Syst Rev. 2016 Jan 07;(1):CD011472
pubmed: 26758499
BMC Genomics. 2016 Mar 01;17:165
pubmed: 26932765
PLoS One. 2016 Apr 21;11(4):e0153893
pubmed: 27100399
J Nutr. 1989 May;119(5):800-4
pubmed: 2723829
Nature. 2016 Jul 21;535(7612):376-81
pubmed: 27409811
Cell Metab. 2016 Jul 12;24(1):151-7
pubmed: 27411015
Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3959-3970
pubmed: 27437760
Front Microbiol. 2016 Jun 28;7:979
pubmed: 27446020
Behav Brain Res. 2017 Jan 1;316:38-46
pubmed: 27566182
Microbiome. 2016 Oct 21;4(1):57
pubmed: 27769291
Anaerobe. 2016 Dec;42:197-204
pubmed: 27794467
Int J Obes (Lond). 2017 Mar;41(3):381-389
pubmed: 27924082
Gastroenterol Clin North Am. 2017 Mar;46(1):77-89
pubmed: 28164854
Adv Exp Med Biol. 2017;960:511-527
pubmed: 28585214
Annu Rev Nutr. 2017 Aug 21;37:157-181
pubmed: 28715991
Front Physiol. 2017 Aug 25;8:602
pubmed: 28890700
J Endocrinol. 2018 Feb;236(2):R105-R108
pubmed: 29321189
J Agric Food Chem. 2018 Jan 31;66(4):881-890
pubmed: 29327584
Am J Clin Nutr. 2018 Mar 1;107(3):436-444
pubmed: 29566200
Anal Chem. 2018 Jul 17;90(14):8487-8494
pubmed: 29920210
Nat Microbiol. 2019 Mar;4(3):396-403
pubmed: 30531975
Cell Host Microbe. 2019 Mar 13;25(3):444-453.e3
pubmed: 30799264
Clin Nutr. 2019 Feb 19;:null
pubmed: 30827722
Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2339-44
pubmed: 9122196