Histone demethylase KDM6B regulates human podocyte differentiation
Benzazepines
/ pharmacology
Cell Differentiation
Gene Expression Regulation, Enzymologic
Histones
/ metabolism
Humans
Jumonji Domain-Containing Histone Demethylases
/ antagonists & inhibitors
Membrane Proteins
/ metabolism
Methylation
/ drug effects
Podocytes
/ cytology
Pyrimidines
/ pharmacology
WT1 Proteins
/ biosynthesis
Histone demethylase
KDM6B
differentiation
podocyte
Journal
The Biochemical journal
ISSN: 1470-8728
Titre abrégé: Biochem J
Pays: England
ID NLM: 2984726R
Informations de publication
Date de publication:
26 06 2019
26 06 2019
Historique:
received:
26
12
2018
revised:
18
05
2019
accepted:
28
05
2019
pubmed:
30
5
2019
medline:
12
2
2020
entrez:
30
5
2019
Statut:
epublish
Résumé
Podocytes are terminally differentiated and highly specialized glomerular cells, which have an essential role as a filtration barrier against proteinuria. Histone methylation has been shown to influence cell development, but its role in podocyte differentiation is less understood. In this study, we first examined the expression pattern of histone demethylase KDM6B at different times of cultured human podocytes
Identifiants
pubmed: 31138771
pii: BCJ20180968
doi: 10.1042/BCJ20180968
doi:
Substances chimiques
Benzazepines
0
GSK-J4
0
Histones
0
Membrane Proteins
0
Pyrimidines
0
WT1 Proteins
0
WT1 protein, human
0
nephrin
0
Jumonji Domain-Containing Histone Demethylases
EC 1.14.11.-
KDM6B protein, human
EC 1.14.11.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1741-1751Informations de copyright
© 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.