Capabilities of fecal calprotectin and blood biomarkers as surrogate endoscopic markers according to ulcerative colitis disease type.

C-reactive protein colonoscopy fecal calprotectin ulcerative colitis

Journal

Journal of clinical biochemistry and nutrition
ISSN: 0912-0009
Titre abrégé: J Clin Biochem Nutr
Pays: Japan
ID NLM: 8700907

Informations de publication

Date de publication:
May 2019
Historique:
received: 01 10 2018
accepted: 19 11 2018
entrez: 30 5 2019
pubmed: 30 5 2019
medline: 30 5 2019
Statut: ppublish

Résumé

Fecal calprotectin level in ulcerative colitis patients is correlated with endoscopic findings. However, its association with various ulcerative colitis disease types has not been elucidated. In the present study, we investigated the correlation of fecal calprotectin level with endoscopic findings as compared to blood biomarkers according to ulcerative colitis disease type. Fecal calprotectin as well as the blood biomarkers: C-reactive protein (CRP), white blood count (WBC), erythrocyte sedimentation rate (ESR), hemoglobin, platelet count (PLT), and serum albumin (Alb) were measured in patients who underwent a complete colonoscopy. Disease type was divided into proctitis, left-sided colitis, and extensive colitis. Correlations of fecal calprotectin and blood biomarker levels with Mayo endoscopic subscore were analyzed. A total of 186 colonoscopy examinations were performed in 124 patients with ulcerative colitis. Fecal calprotectin level showed a significant correlation with Mayo endoscopic subscore regardless of disease type (proctitis, r = 0.54,

Identifiants

pubmed: 31138962
doi: 10.3164/jcbn.18-92
pii: DN/JST.JSTAGE/jcbn/18-92
pmc: PMC6529695
doi:

Types de publication

Journal Article

Langues

eng

Pagination

265-270

Déclaration de conflit d'intérêts

No potential conflicts of interest were disclosed.

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Auteurs

Hiroki Sonoyama (H)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Kousaku Kawashima (K)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
Inflammatory Bowel Disease Center, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Shunji Ishihara (S)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
Inflammatory Bowel Disease Center, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Satoshi Kotani (S)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Nobuhiko Fukuba (N)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Akihiko Oka (A)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Ryusaku Kusunoki (R)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Yasumasa Tada (Y)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Yoshiyuki Mishima (Y)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Naoki Oshima (N)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Ichiro Moriyama (I)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.
Cancer Center, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Takafumi Yuki (T)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Koji Onishi (K)

Division of Internal Medicine, Matsue Seikyo General Hospital, 8-8-8 Nishitsuda, Matsue, Shimane 690-8522, Japan.

Yoshikazu Kinoshita (Y)

Department of Internal Medicine II, Shimane University Hospital, 89-1 Enya-cho, Izumo, Shimane 693-8501, Japan.

Classifications MeSH