Protein interacting with Amyloid Precursor Protein tail-1 (PAT1) is involved in early endocytosis.
Amino Acid Transport Systems
/ genetics
Amyloid beta-Protein Precursor
/ genetics
Animals
Cell Membrane
/ genetics
Endocytosis
/ genetics
Endosomes
/ genetics
Gene Expression Regulation
Humans
Mice
Neurons
/ metabolism
Protein Transport
Receptors, Androgen
/ genetics
Symporters
/ genetics
Vesicular Transport Proteins
/ genetics
rab GTP-Binding Proteins
/ genetics
rab4 GTP-Binding Proteins
/ genetics
rab5 GTP-Binding Proteins
/ genetics
rab7 GTP-Binding Proteins
Caspase cleaved APP
Endocytosis
Neuron
PAT1
Transferrin uptake
Journal
Cellular and molecular life sciences : CMLS
ISSN: 1420-9071
Titre abrégé: Cell Mol Life Sci
Pays: Switzerland
ID NLM: 9705402
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
04
09
2018
accepted:
20
05
2019
revised:
16
05
2019
pubmed:
30
5
2019
medline:
18
12
2019
entrez:
30
5
2019
Statut:
ppublish
Résumé
Protein interacting with Amyloid Precursor Protein (APP) tail 1 (PAT1) also called APPBP2 or Ara 67 has different targets such as APP or androgen receptor and is expressed in several tissues. PAT1 is known to be involved in the subcellular trafficking of its targets. We previously observed in primary neurons that PAT1 is poorly associated with APP at the cell surface. Here we show that PAT1 colocalizes with vesicles close to the cell surface labeled with Rab5, Rab4, EEA1 and Rabaptin-5 but not with Rab11 and Rab7. Moreover, PAT1 expression regulates the number of EEA1 and Rab5 vesicles, and endocytosis/recycling of the transferrin receptor. In addition, low levels of PAT1 decrease the size of transferrin-colocalized EEA1 vesicles with time following transferrin uptake. Finally, overexpression of the APP binding domain to PAT1 is sufficient to compromise endocytosis. Altogether, these data suggest that PAT1 is a new actor in transferrin early endocytosis. Whether this new function of PAT1 may have consequences in pathology remains to be determined.
Identifiants
pubmed: 31139847
doi: 10.1007/s00018-019-03157-7
pii: 10.1007/s00018-019-03157-7
doi:
Substances chimiques
Amino Acid Transport Systems
0
Amyloid beta-Protein Precursor
0
Rabep1 protein, mouse
0
Receptors, Androgen
0
Slc36a1 protein, mouse
0
Symporters
0
Vesicular Transport Proteins
0
early endosome antigen 1
0
rab7 GTP-Binding Proteins
0
rab7 GTP-binding proteins, human
0
rab7 GTP-binding proteins, mouse
0
rab11 protein
EC 3.6.1.-
rab GTP-Binding Proteins
EC 3.6.5.2
rab4 GTP-Binding Proteins
EC 3.6.5.2
rab5 GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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