Mantle Cell Lymphoma With Mantle Zone Growth Pattern.
Cyclin D1
Mantle cell lymphoma
Mantle zone growth pattern
SOX11
Journal
American journal of clinical pathology
ISSN: 1943-7722
Titre abrégé: Am J Clin Pathol
Pays: England
ID NLM: 0370470
Informations de publication
Date de publication:
05 07 2019
05 07 2019
Historique:
pubmed:
30
5
2019
medline:
13
3
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
To characterize the clinical and pathologic features of mantle cell lymphoma with mantle zone growth pattern (MCL-MZGP). The clinicopathologic data from 35 cases of MCL-MZGP obtained in 12 centers were analyzed. The patients with MCL-MZGP typically sought treatment at high clinical stages (81%). Intriguingly, 40% (14/35) of cases were incidentally noted. The lymph nodes with MCL-MZGP showed preserved architecture and expanded mantles containing lymphoma cells with classic or small cell cytology. MCL-MZGP was positive for BCL2 (96%, bright), CD5 (82%, moderate), cyclin D1 (100%), and SOX11 (89%). Clinically, our study revealed no significant difference in the overall survival between patients managed with observation alone and those who received chemotherapy. MCL-MZGP was often incidentally identified and resembled reactive mantles. Therefore, recognition of this unusual morphology emphasizes the utility of cyclin D1 immunostain in the cases with suspicious morphology. However, the clinical significance of these findings is still unclear.
Identifiants
pubmed: 31140550
pii: 5505361
doi: 10.1093/ajcp/aqz043
doi:
Substances chimiques
BCL2 protein, human
0
CD5 Antigens
0
Proto-Oncogene Proteins c-bcl-2
0
SOX11 protein, human
0
SOXC Transcription Factors
0
Cyclin D1
136601-57-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
132-145Commentaires et corrections
Type : CommentIn
Informations de copyright
© American Society for Clinical Pathology, 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.