A red orange and lemon by-products extract rich in anthocyanins inhibits the progression of diabetic nephropathy.
anthocyanins
diabetic nephropathy
reactive oxygen species
renal micropuncture
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
10
04
2019
revised:
07
05
2019
accepted:
08
05
2019
pubmed:
30
5
2019
medline:
13
6
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
The major cause of end-stage renal disease is the diabetic nephropathy. Oxidative stress contributes to the development of type II diabetes mellitus (T2DM). In this study we have evaluated the effect of a diet with a new standardized of red orange and lemon extract (RLE) rich in anthocyanins (ANT) in the progression of the kidney disease on Zucker diabetic fatty rats. Oxidative stress and renal function were analyzed. In diabetic rats, the RLE restored the blood glucose levels, body weight, and normalized the reactive oxygen species (ROS) total pathways. The kidney inflammation, in diabetic rats, has not shown significant change, showing that the oxidative stress rather than to inflammatory processes is a triggering factor in the renal complication associated with T2DM. Therefore, the administration of the RLE prevents this complication and this effect could be related to the inhibition of ROS production.
Substances chimiques
Anthocyanins
0
Antioxidants
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23268-23278Informations de copyright
© 2019 Wiley Periodicals, Inc.