A comprehensive review on miR-451: A promising cancer biomarker with therapeutic potential.
cancer
cancer treatment
dysregulation
miR-451
target
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
11
12
2018
revised:
07
05
2019
accepted:
09
05
2019
pubmed:
30
5
2019
medline:
11
6
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
MicroRNAs (miRNAs) are proposed as a family of short noncoding molecules able to manage and control the expression of the gene targets at the posttranscriptional level. They contribute in several fundamental physiological mechanisms as well as a verity of human and animal diseases such as cancer progression. Among these tiny RNAs, miR-451 placed on chromosome 17 at 17q11.2 presents an essential role in many biological processes in health condition and also in pathogenesis of different diseases. Besides, it has been recently considered as a valuable biomarker for cancer detection, prognosis and treatment. Therefore, this review will provide the critical functions of miR-451 on biological mechanisms including cell cycle and proliferation, cell survival and apoptosis, differentiation and development as well as disease initiation and progression such as tumor formation, migration, invasion, and metastasis.
Substances chimiques
Biomarkers, Tumor
0
MIRN451 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
21716-21731Informations de copyright
© 2019 Wiley Periodicals, Inc.