Impact of Weight Loss Strategies on Obesity-Induced DNA Damage.
DNA damage
DNA repair
Western diet
inflammation
weight loss
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
11
01
2019
revised:
16
05
2019
pubmed:
30
5
2019
medline:
24
3
2020
entrez:
30
5
2019
Statut:
ppublish
Résumé
Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic material. Overweight mice are fed ad libitum either with a Western diet (WD), with a 40% caloric restricted WD, or with a high carbohydrate low protein (HCLP) diet. Caloric restriction and also the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage ("comet" formation) and oxidative damage of purines in inner organs, additionally the activity of nucleotide excision repair increased. The effects are more pronounced in animals that have received the HCLP chow. Results of biochemical analyses indicate that the reduction of DNA damage is associated with a decrease of pro-inflammatory cytokines and lower insulin levels. The study indicates that weight loss may prevent obesity-associated adverse health effects due to reduction of overall DNA damage.
Identifiants
pubmed: 31141317
doi: 10.1002/mnfr.201900045
pmc: PMC6771950
doi:
Substances chimiques
Cytokines
0
Dietary Carbohydrates
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900045Subventions
Organisme : Austrian Science Fund FWF
ID : P 27129
Pays : Austria
Informations de copyright
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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