Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts.

Animals Heterografts Humans Neoplasms Pharmacogenetics Precision Medicine Xenograft Model Antitumor Assays

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
01 Sep 2019
Historique:
received: 31 01 2019
revised: 16 04 2019
accepted: 23 05 2019
pubmed: 31 5 2019
medline: 26 9 2019
entrez: 31 5 2019
Statut: ppublish

Résumé

Identifying robust biomarkers of drug response constitutes a key challenge in precision medicine. Patient-derived tumor xenografts (PDX) have emerged as reliable preclinical models that more accurately recapitulate tumor response to chemo- and targeted therapies. However, the lack of computational tools makes it difficult to analyze high-throughput molecular and pharmacologic profiles of PDX. We have developed Xenograft Visualization & Analysis (Xeva), an open-source software package for

Identifiants

DOI: 10.1158/0008-5472.CAN-19-0349 PMID: 31142512
pubmed: 31142512
pii: 0008-5472.CAN-19-0349
doi: 10.1158/0008-5472.CAN-19-0349
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4539-4550

Commentaires et corrections

Type : CommentIn

Informations de copyright

©2019 American Association for Cancer Research.

Auteurs

Arvind S Mer (AS)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Wail Ba-Alawi (W)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Petr Smirnov (P)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0001-9395-8450

Yi X Wang (YX)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

Ben Brew (B)

Hospital for Sick Children, Toronto, Ontario, Canada.

Janosch Ortmann (J)

Département de Management et Technologie, Université du Québec à Montréal, Montreal, Quebec, Canada.
ORCID: 0000-0002-3811-6047

Ming-Sound Tsao (MS)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
ORCID: 0000-0002-9160-5405

David W Cescon (DW)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

Anna Goldenberg (A)

Hospital for Sick Children, Toronto, Ontario, Canada.
Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Vector Institute, Toronto, Ontario, Canada.

Benjamin Haibe-Kains (B)

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. benjamin.haibe.kains@utoronto.ca.
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.
Vector Institute, Toronto, Ontario, Canada.
Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
ORCID: 0000-0002-7684-0079

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Integrative Pharmacogenomics Analysis of...
questionsmedicales.fr › Régions du corps › Transplants › Hétérogreffes › Integrative Pharmacogenomics Analysis of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrative Pharmacogenomics Analysis of...
questionsmedicales.fr › Tumeurs › Integrative Pharmacogenomics Analysis of...
questionsmedicales.fr › Professions de santé › Pharmacologie › Pharmacogénétique › Integrative Pharmacogenomics Analysis of...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › Integrative Pharmacogenomics Analysis of...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Integrative Pharmacogenomics Analysis of...