Elastography of multicellular spheroids using 3D light microscopy.


Journal

Biomedical optics express
ISSN: 2156-7085
Titre abrégé: Biomed Opt Express
Pays: United States
ID NLM: 101540630

Informations de publication

Date de publication:
01 May 2019
Historique:
received: 12 02 2019
revised: 04 04 2019
accepted: 09 04 2019
entrez: 31 5 2019
pubmed: 31 5 2019
medline: 31 5 2019
Statut: epublish

Résumé

We have demonstrated a new method of 3D elastography based on 3D light microscopy and micro-scale manipulation. We used custom-built micromanipulators to apply a mechanical force onto multicellular tumor spheroids (200-300 µm in size) and recorded the induced compression with a differential interference contrast (DIC)/confocal microscope to obtain a 4D (x, y, z, and indentation steps) image sequence. Deformation analysis made through 3D pattern tracking without using fluorescence revealed 3D structural and spatial heterogeneity in tumor spheroids. We observed a 20-30 µm-sized spot of locally-induced large deformation within a tumor spheroid. We also found solid fibroblast cores formed in a tumor-fibroblast co-culture spheroid to be stiffer than surrounding cancer cells, which would not have been discovered using only conventional fluorescence. Our new method of 3D elastography may be used to better understand structural composition in multicellular spheroids through analysis of mechanical heterogeneity.

Identifiants

pubmed: 31143496
doi: 10.1364/BOE.10.002409
pii: 358820
pmc: PMC6524572
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2409-2418

Déclaration de conflit d'intérêts

The authors declare that there are no conflicts of interest related to this article.

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Auteurs

Devina Jaiswal (D)

Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Rd, Storrs, Connecticut 06269, USA.
Department of Biomedical Engineering, Western New England University, 1215 Wilbraham Rd, Springfield, Massachusetts 01119, USA.

Zoe Moscato (Z)

Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Rd, Storrs, Connecticut 06269, USA.

Yuji Tomizawa (Y)

Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Rd, Storrs, Connecticut 06269, USA.

Kevin P Claffey (KP)

Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Ave, Farmington, Connecticut 06030, USA.

Kazunori Hoshino (K)

Department of Biomedical Engineering, University of Connecticut, 260 Glenbrook Rd, Storrs, Connecticut 06269, USA.

Classifications MeSH