Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.

Aging / physiology Animals Brain / blood supply Cell Movement / physiology Cell Proliferation / physiology Cognitive Dysfunction / prevention & control Endothelial Cells / physiology Hydrogen Peroxide / metabolism Microvessels / cytology Neovascularization, Physiologic / drug effects Nicotinamide Mononucleotide / pharmacology Oxidative Stress / drug effects Rats, Inbred BN Rats, Inbred F344
Endothelial dysfunction Microcirculation NAD+ precursor Senescence Vascular contributions to cognitive impairment and dementia

Journal

GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284

Informations de publication

Date de publication:
10 2019
Historique:
received: 11 05 2019
accepted: 16 05 2019
revised: 11 05 2019
pubmed: 31 5 2019
medline: 22 5 2020
entrez: 31 5 2019
Statut: ppublish

Résumé

Age-related impairment of angiogenesis likely has a critical role in cerebromicrovascular rarefaction and development of vascular cognitive impairment and dementia (VCID) in the elderly. Recently, we demonstrated that aging is associated with NAD

Identifiants

DOI: 10.1007/s11357-019-00074-2 PMID: 31144244 PMC: PMC6885080
pubmed: 31144244
doi: 10.1007/s11357-019-00074-2
pii: 10.1007/s11357-019-00074-2
pmc: PMC6885080
doi:

Substances chimiques

Nicotinamide Mononucleotide 1094-61-7
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

619-630

Subventions

Organisme : NIGMS NIH HHS
ID : U54 GM104938
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103447
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055395
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047879
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS100782
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS056218
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG038747
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG055395
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG047879
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM125528
Pays : United States

Références

Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H736-44
pubmed: 21186274
NPJ Aging Mech Dis. 2016 Aug 18;2:16017
pubmed: 28721271
Geroscience. 2017 Apr;39(2):175-186
pubmed: 28283797
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1876-81
pubmed: 19749157
Brain Cogn. 1989 May;10(1):28-43
pubmed: 2713143
Geroscience. 2018 Apr;40(2):105-121
pubmed: 29679203
PLoS One. 2012;7(1):e30444
pubmed: 22279591
Geroscience. 2018 Dec;40(5-6):453-468
pubmed: 30121784
J Gerontol A Biol Sci Med Sci. 2012 Aug;67(8):821-9
pubmed: 22219515
Circ Res. 2012 Apr 27;110(9):1252-64
pubmed: 22539758
Nat Rev Mol Cell Biol. 2016 Nov;17(11):679-690
pubmed: 27552971
AJR Am J Roentgenol. 1999 Jan;172(1):213-8
pubmed: 9888770
Exp Aging Res. 1993 Jul-Sep;19(3):225-40
pubmed: 8223824
J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):587-98
pubmed: 22522510
Science. 2016 Jun 17;352(6292):1436-43
pubmed: 27127236
J Cereb Blood Flow Metab. 1991 Jul;11(4):684-9
pubmed: 2050757
Geroscience. 2017 Aug;39(4):385-406
pubmed: 28664509
Am J Physiol Heart Circ Physiol. 2014 Aug 1;307(3):H292-306
pubmed: 24906921
J Gerontol A Biol Sci Med Sci. 2013 Aug;68(8):877-91
pubmed: 23239824
Geroscience. 2019 Feb;41(1):25-38
pubmed: 30547325
Geroscience. 2018 Feb;40(1):11-29
pubmed: 29327208
J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):665-74
pubmed: 25136000
Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1253-H1266
pubmed: 30875255
Geroscience. 2017 Feb;39(1):33-42
pubmed: 28299642
Cell Metab. 2016 Dec 13;24(6):795-806
pubmed: 28068222
Neurobiol Aging. 2012 May;33(5):1004.e1-16
pubmed: 22019053
Endocrinology. 1997 Aug;138(8):3515-20
pubmed: 9231806
J Neurol Sci. 2000 Dec 1;181(1-2):19-28
pubmed: 11099707
Age (Dordr). 2016 Aug;38(4):273-289
pubmed: 27613724
J Gerontol A Biol Sci Med Sci. 2001 Aug;56(8):B364-71
pubmed: 11487595
Eur J Nucl Med Mol Imaging. 2002 Jan;29(1):67-75
pubmed: 11807609
J Cereb Blood Flow Metab. 1996 May;16(3):385-98
pubmed: 8621743
NPJ Aging Mech Dis. 2018 Nov 8;4:10
pubmed: 30416740
Geroscience. 2018 Jun 18;:null
pubmed: 29916025
Geroscience. 2017 Jun;39(3):347-356
pubmed: 28523599
Neurobiol Aging. 1999 Mar-Apr;20(2):191-200
pubmed: 10537028
Geroscience. 2017 Dec;39(5-6):475-489
pubmed: 29159506
Ageing Res Rev. 2003 Apr;2(2):149-68
pubmed: 12605958
Nat Rev Neurosci. 2011 Nov 03;12(12):723-38
pubmed: 22048062
Cell Metab. 2018 Mar 6;27(3):513-528
pubmed: 29249689
J Anat. 2000 Nov;197 Pt 4:575-85
pubmed: 11197531
Cell. 2018 Mar 22;173(1):74-89.e20
pubmed: 29570999
Geroscience. 2018 Apr;40(2):163-176
pubmed: 29717417
Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H1-H20
pubmed: 27793855
J Histochem Cytochem. 2003 Sep;51(9):1119-30
pubmed: 12923237
Trends Endocrinol Metab. 2009 Apr;20(3):130-8
pubmed: 19109034
Cell Metab. 2016 Jun 14;23(6):965-966
pubmed: 27304496
J Gerontol A Biol Sci Med Sci. 2003 Sep;58(9):B798-805
pubmed: 14528035
Geroscience. 2018 Dec;40(5-6):469-484
pubmed: 30136078
J Cell Physiol. 2005 Sep;204(3):800-7
pubmed: 15795937
Mech Ageing Dev. 2005 Apr;126(4):467-73
pubmed: 15722105
Geroscience. 2018 Jun 21;:null
pubmed: 29931650
Geroscience. 2018 Aug;40(4):359-360
pubmed: 30088182
Nat Rev Cardiol. 2018 Sep;15(9):555-565
pubmed: 29795441
Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H299-308
pubmed: 24322615
J Gerontol A Biol Sci Med Sci. 2013 Mar;68(3):235-49
pubmed: 22904098
Geroscience. 2017 Dec;39(5-6):601-614
pubmed: 29243191
Geroscience. 2018 Dec;40(5-6):513-521
pubmed: 30470983
Geroscience. 2017 Apr;39(2):187-198
pubmed: 28409332
J Cereb Blood Flow Metab. 2013 Nov;33(11):1732-42
pubmed: 23942363
J Gerontol A Biol Sci Med Sci. 2008 Jan;63(1):12-20
pubmed: 18245756
Int J Mol Sci. 2017 Sep 04;18(9):null
pubmed: 28869535
Geroscience. 2017 Aug;39(4):359-372
pubmed: 28853030
Neuroscience. 2009 Dec 15;164(3):918-28
pubmed: 19735701
Neuroreport. 1999 Aug 20;10(12):2493-6
pubmed: 10574358
Front Aging Neurosci. 2009 Dec 09;1:4
pubmed: 20552055
J Gerontol A Biol Sci Med Sci. 2014 Nov;69(11):1339-52
pubmed: 24895269
Redox Biol. 2019 Jun;24:101192
pubmed: 31015147
Geroscience. 2018 Dec;40(5-6):485-496
pubmed: 30288646
Geroscience. 2018 Aug;40(4):365-375
pubmed: 30074132
Prog Neurobiol. 2001 Aug;64(6):575-611
pubmed: 11311463
Geroscience. 2018 Dec;40(5-6):437-452
pubmed: 30345481
J Gerontol A Biol Sci Med Sci. 2012 Jun;67(6):599-610
pubmed: 22451468
Circ Res. 2018 Sep 14;123(7):849-867
pubmed: 30355080
Aging Cell. 2016 Jun;15(3):522-30
pubmed: 26970090
Geroscience. 2017 Apr;39(2):147-160
pubmed: 28233247
Cell. 2013 Dec 19;155(7):1624-38
pubmed: 24360282
J Gerontol A Biol Sci Med Sci. 2014 Oct;69(10):1212-26
pubmed: 24269929
Geroscience. 2017 Dec;39(5-6):491-498
pubmed: 28875415
PLoS One. 2012;7(6):e38692
pubmed: 22719923
Geroscience. 2017 Aug;39(4):465-473
pubmed: 28578467
Aging Cell. 2018 Apr;17(2):
pubmed: 29405550
PLoS One. 2012;7(7):e42357
pubmed: 22848760
Cell. 2007 Sep 21;130(6):1095-107
pubmed: 17889652

Auteurs

Tamas Kiss (T)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.
Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Theoretical Medicine Doctoral School, University of Szeged, Szeged, Hungary.

Priya Balasubramanian (P)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

Marta Noa Valcarcel-Ares (MN)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

Stefano Tarantini (S)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

Andriy Yabluchanskiy (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.

Tamas Csipo (T)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.
Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.

Agnes Lipecz (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.
Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.

Dora Reglodi (D)

Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, Pecs, Hungary.

Xin A Zhang (XA)

Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Ferenc Bari (F)

Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Theoretical Medicine Doctoral School, University of Szeged, Szeged, Hungary.

Eszter Farkas (E)

Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Theoretical Medicine Doctoral School, University of Szeged, Szeged, Hungary.

Anna Csiszar (A)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA.
Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary.
Theoretical Medicine Doctoral School, University of Szeged, Szeged, Hungary.

Zoltan Ungvari (Z)

Vascular Cognitive Impairment and Neurodegeneration Program, Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1311, Oklahoma City, OK, 73104, USA. zoltan-ungvari@ouhsc.edu.
Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary. zoltan-ungvari@ouhsc.edu.
Theoretical Medicine Doctoral School, University of Szeged, Szeged, Hungary. zoltan-ungvari@ouhsc.edu.
Department of Public Health, Semmelweis University, Budapest, Hungary. zoltan-ungvari@ouhsc.edu.
Department of Health Promotion Sciences, the Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. zoltan-ungvari@ouhsc.edu.
ORCID: 0000-0002-6035-6039

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Eucaryotes › Animaux › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Microvaisseaux › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Néovascularisation physiologique › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nicotinamide mononucléotide › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée BN › Nicotinamide mononucleotide (NMN) treatment...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée F344 › Nicotinamide mononucleotide (NMN) treatment...