CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.

Aged Aged, 80 and over Alzheimer Disease / blood Brain Cohort Studies CpG Islands / genetics DNA Methylation / genetics Dinucleoside Phosphates / genetics Female Genetic Predisposition to Disease / genetics Genome-Wide Association Study Humans Male Membrane Proteins / genetics Middle Aged Polymorphism, Single Nucleotide Prognosis Quantitative Trait Loci Risk
Alzheimer disease DNA methylation eQTL epigenetics genetics mQTL

Journal

Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839

Informations de publication

Date de publication:
08 2019
Historique:
received: 18 09 2018
revised: 04 04 2019
accepted: 13 04 2019
pubmed: 31 5 2019
medline: 8 7 2020
entrez: 31 5 2019
Statut: ppublish

Résumé

CpG-related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome-wide association study using a sliding-window approach to measure the combined effects of CGSes on AD risk in a discovery sample of 24 European ancestry cohorts (12,181 cases, 12,601 controls) from the Alzheimer's Disease Genetics Consortium (ADGC) and replication sample of seven European ancestry cohorts (7,554 cases, 27,382 controls) from the International Genomics of Alzheimer's Project (IGAP). The potential functional relevance of significant associations was evaluated by analysis of methylation and expression levels in brain tissue of the Religious Orders Study and the Rush Memory and Aging Project (ROSMAP), and in whole blood of Framingham Heart Study participants (FHS). Genome-wide significant (p < 5 × 10

Identifiants

DOI: 10.1111/acel.12964 PMID: 31144443 PMC: PMC6612647
pubmed: 31144443
doi: 10.1111/acel.12964
pmc: PMC6612647
doi:

Substances chimiques

Dinucleoside Phosphates 0
MS4A4A protein, human 0
Membrane Proteins 0
cytidylyl-3'-5'-guanosine 2382-65-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e12964

Subventions

Organisme : NIA NIH HHS
ID : P30 AG053760
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016573
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG048927
Pays : United States
Organisme : NIA NIH HHS
ID : U01-AG46152
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054023
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG023501
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG028383
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010161
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047366
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG036042
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : Medical Research Council
ID : MR/K01417X/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG049638
Pays : United States
Organisme : Medical Research Council
ID : G0902227
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L023784/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P50 AG005133
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG36042
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010124
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057519
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010133
Pays : United States
Organisme : Medical Research Council
ID : MR/L501542/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P50 AG005146
Pays : United States
Organisme : Medical Research Council
ID : MR/M009076/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P50 AG008702
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG016976
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005136
Pays : United States
Organisme : NIA NIH HHS
ID : U24-AG041689-01
Pays : United States
Organisme : Parkinson's UK
ID : G-0907
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG056270
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047266
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG017917
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG17917
Pays : United States
Organisme : Medical Research Council
ID : MR/N026004/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG012300
Pays : United States
Organisme : Medical Research Council
ID : MR/K013041/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30 AG008051
Pays : United States
Organisme : NIA NIH HHS
ID : RC2 AG036528
Pays : United States
Organisme : NIA NIH HHS
ID : RF1-AG057519
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG041689
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG036042
Pays : United States
Organisme : NIA NIH HHS
ID : R01-AG048927
Pays : United States
Organisme : Medical Research Council
ID : G0300429
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U01 AG032984
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG047270
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005138
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005131
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG019610
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005142
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG008017
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013854
Pays : United States
Organisme : Medical Research Council
ID : MR/L023784/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0701075
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P50 AG025688
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013846
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG035982
Pays : United States
Organisme : Medical Research Council
ID : G0901254
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P30-AG10161
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005134
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG033514
Pays : United States
Organisme : Medical Research Council
ID : MR/L501517/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG015819
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2019 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

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Auteurs

Yiyi Ma (Y)

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Center for Translational & Computational Neuroimmunology, Multiple Sclerosis Clinical Care and Research Center, Division of Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York.
ORCID: 0000-0002-3609-8877

Gyungah R Jun (GR)

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts.

Jaeyoon Chung (J)

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.

Xiaoling Zhang (X)

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.

Brian W Kunkle (BW)

John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida.

Adam C Naj (AC)

Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Charles C White (CC)

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's, Boston, Massachusetts.
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.

David A Bennett (DA)

Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois.

Philip L De Jager (PL)

Center for Translational & Computational Neuroimmunology, Multiple Sclerosis Clinical Care and Research Center, Division of Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York.
Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's, Boston, Massachusetts.
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts.

Richard Mayeux (R)

Department of Neurology and Sergievsky Center, Columbia University, New York, New York.

Jonathan L Haines (JL)

Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio.

Margaret A Pericak-Vance (MA)

John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida.

Gerard D Schellenberg (GD)

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Lindsay A Farrer (LA)

Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, Massachusetts.
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.
Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts.
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts.

Kathryn L Lunetta (KL)

Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Ilots CpG › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Dinucléoside phosphates › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Diagnostic › Pronostic › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › CpG-related SNPs in the MS4A region have a...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › CpG-related SNPs in the MS4A region have a...